FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4235370636> ?p ?o ?g. }

• W4235370636 endingPage "168" @default.
• W4235370636 startingPage "153" @default.
• W4235370636 abstract "Observations were made of influence of acute and chronic reserpinization upon the pressor effects of intravenously administered ephedrine-like (Ephlike) drugs and on tachyphylaxis arising from repeated dosage of these drugs in atropinized dogs under morphine-pentobarbital anesthesia. 1) In acutely reserpinized dogs, repeated administration of ephedrine (Eph), methamphetamine (Met), Pheniprazine (Ph) and tyramine (Ty) at dosage level of 0.5 mg/kg caused pressor effects more prominent consistently and slightly than in unreserpinized ones. With Eph, Met and Ty administered repeatedly in doses of 1 mg/kg, diminution of the pressor response was noted to be more slightly marked in the dogs given reserpine (Res) than that in the unreserpinized controls ; hence a slight enhancement of tachyphylaxis to these drugs by acute reserpinization. With Ph, in contrast, marked pressor effects occurred repeatedly and the tachyphylactic tendency was accordingly allayed to a considerable extent. If Res was intitially injected the tachyphylactic response to Eph, Met and Ty was somewhat profound in an occasional case, yet the development of tachyphylaxis was not significantly hastened by the administration of Res. 2) In animals with tachyphylactic response to repeated Eph, Met or Ph dosage with the consequent disappearance of pressor effects, reserpinization gave rise to a persistent elevation in blood pressure even after the appearance of hypotension (reversal effect). Res, however, failed to bring about any conspicuous rise in blood pressure when it was injected after disappearance of the pressor response following repeated high dosage of Ty. After reserpinization no alterations in the pattern of blood pressure lowering response (reversal effect) were noted to occur with Eph, Met and Ph, whereas with Ty, a slight recovery to pressor effects occurred. 3) A tendency was noted to exsist for the cross tachyphylaxis with these Eph-like drugs to be some what conspicuously provoked by the administration of Res. Especially, the pressor effect of Ty was observed to be somewhat markedly diminished with an augmentation of tachyphylaxis in animals having been received Res plus Eph or Met. 4) In chronically reserpinized dogs, the pressor response to Eph-like drugs was remarkably modest from the beginnig and further gradually diminished, yet never subsided, as the drugs were injected repeatedly. These results obtained indicate that acute or chronic reserpinization may in some instances slightly enhance the tachyphylactic tendency to Eph-like drugs, but cause no particularly rapid disappearance of pressor effect, and that the norepinephrine (Nor) depletion by Res and the development of tachyphylaxis to these drugs have not particularly intimate relation to each other. Furthermore, the mechanism of actions of Eph-like agents was also discussed." @default.
• W4235370636 created "2022-05-12" @default.
• W4235370636 creator A5064337238 @default.
• W4235370636 creator A5074971816 @default.
• W4235370636 creator A5086356090 @default.
• W4235370636 date "1972-01-01" @default.
• W4235370636 modified "2023-09-26" @default.
• W4235370636 title "TACHYPHYLAXIS OF INDIRECTLY ACTING SYMPATHOMIMETIC AMINES" @default.
• W4235370636 doi "https://doi.org/10.2739/kurumemedj.19.153" @default.
• W4235370636 hasPublicationYear "1972" @default.
• W4235370636 type Work @default.
• W4235370636 citedByCount "1" @default.
• W4235370636 crossrefType "journal-article" @default.
• W4235370636 hasAuthorship W4235370636A5064337238 @default.
• W4235370636 hasAuthorship W4235370636A5074971816 @default.
• W4235370636 hasAuthorship W4235370636A5086356090 @default.
• W4235370636 hasBestOaLocation W42353706361 @default.
• W4235370636 hasConcept C126322002 @default.
• W4235370636 hasConcept C168481208 @default.
• W4235370636 hasConcept C170493617 @default.
• W4235370636 hasConcept C2776077682 @default.
• W4235370636 hasConcept C2776755955 @default.
• W4235370636 hasConcept C2776885963 @default.
• W4235370636 hasConcept C2777842393 @default.
• W4235370636 hasConcept C2777953023 @default.
• W4235370636 hasConcept C2778984665 @default.
• W4235370636 hasConcept C2779624279 @default.
• W4235370636 hasConcept C3019263340 @default.
• W4235370636 hasConcept C34400551 @default.
• W4235370636 hasConcept C42219234 @default.
• W4235370636 hasConcept C71924100 @default.
• W4235370636 hasConcept C84393581 @default.
• W4235370636 hasConcept C98274493 @default.
• W4235370636 hasConceptScore W4235370636C126322002 @default.
• W4235370636 hasConceptScore W4235370636C168481208 @default.
• W4235370636 hasConceptScore W4235370636C170493617 @default.
• W4235370636 hasConceptScore W4235370636C2776077682 @default.
• W4235370636 hasConceptScore W4235370636C2776755955 @default.
• W4235370636 hasConceptScore W4235370636C2776885963 @default.
• W4235370636 hasConceptScore W4235370636C2777842393 @default.
• W4235370636 hasConceptScore W4235370636C2777953023 @default.
• W4235370636 hasConceptScore W4235370636C2778984665 @default.
• W4235370636 hasConceptScore W4235370636C2779624279 @default.
• W4235370636 hasConceptScore W4235370636C3019263340 @default.
• W4235370636 hasConceptScore W4235370636C34400551 @default.
• W4235370636 hasConceptScore W4235370636C42219234 @default.
• W4235370636 hasConceptScore W4235370636C71924100 @default.
• W4235370636 hasConceptScore W4235370636C84393581 @default.
• W4235370636 hasConceptScore W4235370636C98274493 @default.
• W4235370636 hasIssue "3" @default.
• W4235370636 hasLocation W42353706361 @default.
• W4235370636 hasOpenAccess W4235370636 @default.
• W4235370636 hasPrimaryLocation W42353706361 @default.
• W4235370636 hasRelatedWork W1973505919 @default.
• W4235370636 hasRelatedWork W1978796004 @default.
• W4235370636 hasRelatedWork W2053975231 @default.
• W4235370636 hasRelatedWork W2071691953 @default.
• W4235370636 hasRelatedWork W2107819670 @default.
• W4235370636 hasRelatedWork W2269629405 @default.
• W4235370636 hasRelatedWork W2306362017 @default.
• W4235370636 hasRelatedWork W2332457742 @default.
• W4235370636 hasRelatedWork W2354748807 @default.
• W4235370636 hasRelatedWork W2515917444 @default.
• W4235370636 hasVolume "19" @default.
• W4235370636 isParatext "false" @default.
• W4235370636 isRetracted "false" @default.
• W4235370636 workType "article" @default.