FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4235471011> ?p ?o ?g. }

• W4235471011 abstract "A 5′-terminal cap is added to most eukaryotic cellular and viral messenger ribonucleic acids (mRNAs) at an early stage of transcription. Capping is essential and modulates several subsequent events in gene expression including pre-mRNA splicing, 3′-poly(A) addition, overall stability, nuclear exit to cytoplasm, protein synthesis, and mRNA turnover initiated by decapping. These and other effects involve cap-binding proteins that recognise the m7GpppN cap structure. Capping proceeds by a similar series of enzymatic steps in a wide range of systems, but differences exist between metazoans and unicellular eukaryotes and viruses, pointing to capping enzymes as potential targets for the development of selective drugs against some fungal, viral and parasitic infections. Moreover, the unique structural features of caps enable us to define the initiation sites and promoter regions of gene transcription, and provide a basis for advanced sequencer-mediated high-throughput genome-wide profiling of gene expression in a wide range of cell types. Key Concepts: mRNA caps are now known to be essential components of gene expression in eukaryotic organisms. The history of the discovery of the presence of 5′ caps on messenger RNA and its subsequent scientific flowering is a good example of how a seemingly small biochemical observation can lead to the deeper understanding of a wide range of fundamental molecular biological phenomena. Evolution has resulted in wide variations in capping structure and function among organisms ranging from viruses to humans; the selective forces underlying such variation requires more research. Research that has documented viral-specific capping reactions in viruses should prove to be a fertile source of research leading to new and novel anti-viral agents. The ‘cap-snatching’ strategies of influenza viruses is a remarkable example of an apparent adaptation to enhance infectivity and is a particularly compelling target for therapeutic intervention. The NMD mRNA surveillance pathway, which includes a pioneer round of translation with cap-binding proteins, results in a striking decrease of defective mRNA in cells of patients with genetic diseases containing premature termination codons. Methylation of genomic DNA and mRNA is now widely accepted as a major pathway of the regulation of both transcription and translation in eukaryotes. Protein synthesis is a major field of gene expression where many players work for mRNA capping, decapping, decoding, quality control of gene transcripts and peptide elongation. Micro RNAs are now widely accepted as major players in the translational control of protein synthesis. The analysis of cap-trapped sequences by high-throughput sequencers enables one to carry out a genome-wide identification of promoters together with quantification of their expression, thus elucidating a promoter-based network of transcriptional regulation." @default.
• W4235471011 created "2022-05-12" @default.
• W4235471011 creator A5000544104 @default.
• W4235471011 date "2014-07-15" @default.
• W4235471011 modified "2023-10-17" @default.
• W4235471011 title "Caps on Eukaryotic m <scp>RNA</scp> s" @default.
• W4235471011 cites W1532353504 @default.
• W4235471011 cites W1600954550 @default.
• W4235471011 cites W1639795491 @default.
• W4235471011 cites W1645492839 @default.
• W4235471011 cites W1966735041 @default.
• W4235471011 cites W1969311457 @default.
• W4235471011 cites W1973931828 @default.
• W4235471011 cites W1978013460 @default.
• W4235471011 cites W1978193049 @default.
• W4235471011 cites W1979969348 @default.
• W4235471011 cites W1982098698 @default.
• W4235471011 cites W1986223165 @default.
• W4235471011 cites W1997971074 @default.
• W4235471011 cites W2004030503 @default.
• W4235471011 cites W2004731223 @default.
• W4235471011 cites W2010692119 @default.
• W4235471011 cites W2015532290 @default.
• W4235471011 cites W2015845481 @default.
• W4235471011 cites W2029910472 @default.
• W4235471011 cites W2031345354 @default.
• W4235471011 cites W2033115718 @default.
• W4235471011 cites W2034544753 @default.
• W4235471011 cites W2035445900 @default.
• W4235471011 cites W2037313242 @default.
• W4235471011 cites W2045281368 @default.
• W4235471011 cites W2046379971 @default.
• W4235471011 cites W2046828533 @default.
• W4235471011 cites W2047602256 @default.
• W4235471011 cites W2050362152 @default.
• W4235471011 cites W2056726430 @default.
• W4235471011 cites W2057906496 @default.
• W4235471011 cites W2061747833 @default.
• W4235471011 cites W2067024190 @default.
• W4235471011 cites W2069002190 @default.
• W4235471011 cites W2075511135 @default.
• W4235471011 cites W2077936726 @default.
• W4235471011 cites W2083070222 @default.
• W4235471011 cites W2084459589 @default.
• W4235471011 cites W2091436625 @default.
• W4235471011 cites W2094885637 @default.
• W4235471011 cites W2095842290 @default.
• W4235471011 cites W2096356762 @default.
• W4235471011 cites W2096688350 @default.
• W4235471011 cites W2096744132 @default.
• W4235471011 cites W2097798503 @default.
• W4235471011 cites W2101124194 @default.
• W4235471011 cites W2116803182 @default.
• W4235471011 cites W2121938543 @default.
• W4235471011 cites W2143350291 @default.
• W4235471011 cites W2156508926 @default.
• W4235471011 cites W2157497892 @default.
• W4235471011 cites W2158079842 @default.
• W4235471011 cites W2159638567 @default.
• W4235471011 cites W2159767268 @default.
• W4235471011 cites W2163106706 @default.
• W4235471011 cites W2168847939 @default.
• W4235471011 cites W4214807762 @default.
• W4235471011 cites W586185249 @default.
• W4235471011 doi "https://doi.org/10.1002/9780470015902.a0000891.pub3" @default.
• W4235471011 hasPublicationYear "2014" @default.
• W4235471011 type Work @default.
• W4235471011 citedByCount "3" @default.
• W4235471011 countsByYear W42354710112018 @default.
• W4235471011 countsByYear W42354710112020 @default.
• W4235471011 countsByYear W42354710112021 @default.
• W4235471011 crossrefType "other" @default.
• W4235471011 hasAuthorship W4235471011A5000544104 @default.
• W4235471011 hasConcept C104317684 @default.
• W4235471011 hasConcept C105580179 @default.
• W4235471011 hasConcept C137404119 @default.
• W4235471011 hasConcept C138885662 @default.
• W4235471011 hasConcept C150194340 @default.
• W4235471011 hasConcept C179926584 @default.
• W4235471011 hasConcept C41895202 @default.
• W4235471011 hasConcept C54355233 @default.
• W4235471011 hasConcept C54458228 @default.
• W4235471011 hasConcept C67705224 @default.
• W4235471011 hasConcept C70721500 @default.
• W4235471011 hasConcept C86803240 @default.
• W4235471011 hasConcept C95444343 @default.
• W4235471011 hasConceptScore W4235471011C104317684 @default.
• W4235471011 hasConceptScore W4235471011C105580179 @default.
• W4235471011 hasConceptScore W4235471011C137404119 @default.
• W4235471011 hasConceptScore W4235471011C138885662 @default.
• W4235471011 hasConceptScore W4235471011C150194340 @default.
• W4235471011 hasConceptScore W4235471011C179926584 @default.
• W4235471011 hasConceptScore W4235471011C41895202 @default.
• W4235471011 hasConceptScore W4235471011C54355233 @default.
• W4235471011 hasConceptScore W4235471011C54458228 @default.
• W4235471011 hasConceptScore W4235471011C67705224 @default.
• W4235471011 hasConceptScore W4235471011C70721500 @default.
• W4235471011 hasConceptScore W4235471011C86803240 @default.
• W4235471011 hasConceptScore W4235471011C95444343 @default.
• W4235471011 hasLocation W42354710111 @default.

• next