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• W4235517978 abstract "Abstract Background The oncologic and functional outcome of transoral laser microsurgery (TLM) for primary treatment of hypopharyngeal cancer was examined in a multimodal treatment concept. Methods Two hundred eleven patients with squamous cell carcinoma (SCC) of the hypopharynx (pT1‐4a, pN0‐2, M0) were treated by TLM +/− neck dissection (88%) +/− (chemo)radiotherapy ([C]RT; 51%). The majority of cases were advanced stages III and IVa (85%). Results The 5‐year Kaplan‐Meier estimates for local control after TLM were pT category‐related 88.1%, 74.8%, 77.3%, and 61.8% for pT1‐4a tumors. The 5‐year estimates of overall survival (OS), disease‐specific survival (DSS), and recurrence‐free survival (RFS) for early stages I and II were 68.2%, 96.7%, and 74.6%, respectively; for stage III they were 65.9%, 83.8%, and 56.4%, respectively; and the rates for stage IVa were 44.5%, 60.7%, and 50.3%, respectively. Overall, 95.7% of the patients maintained regular oral nutrition without feeding tube dependency. Conclusion Primary TLM in multimodal concepts of treatment (+/− neck dissection, +/− [C]RT) offers favorable oncologic results as compared with other therapeutic regimes." @default.
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• W4235517978 date "2017-05-05" @default.
• W4235517978 modified "2023-10-16" @default.
• W4235517978 title "Transoral laser microsurgery for treatment for hypopharyngeal cancer in 211 patients" @default.
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• W4235517978 doi "https://doi.org/10.1002/hed.24814" @default.
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