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- W4235529307 abstract "Studies of Therapy Class Bias risk Study design Criteria I Low risk Study adheres to commonly held tenets of high quality design, execution and avoidance of bias Good quality RCT • Random sequence generation • Allocation concealment • Intent-to-treat analysis • Blind or independent assessment for important outcomes • Co-interventions applied equally • F/U rate of 80%+ • Adequate sample size II Moderately low risk Study has potential for some bias; study does not meet all criteria for class I, but deficiencies not likely to invalidate results or introduce significant bias Moderate or poor quality RCT Good quality cohort • Violation of one of the criteria for good quality RCT • Blind or independent assessment in a prospective study, or use of reliable data[a] in a retrospective study • Co-interventions applied equally • F/U rate of 80%+ • Adequate sample size • Controlling for possible confounding[b] III Moderately High risk Study has significant flaws in design and/or execution that increase potential for bias that may invalidate study results Moderate or poor quality cohort Case-control • Violation of any of the criteria for good quality cohort • Any case-control design IV High risk Study has significant potential for bias; lack of comparison group precludes direct assessment of important outcomes Case series • Any case series design a Outcome assessment is independent of healthcare personnel judgment. Reliable data are data such as mortality or re-operation. b Authors must provide a description of robust baseline characteristics, and control for those that are unequally distributed between treatment groups." @default.
- W4235529307 created "2022-05-12" @default.
- W4235529307 date "2013-11-23" @default.
- W4235529307 modified "2023-09-30" @default.
- W4235529307 title "Definition of Classes of Evidence (CoE) and Overall Strength of Evidence (SoE)" @default.
- W4235529307 doi "https://doi.org/10.1055/s-0033-1363168" @default.
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