Matches in SemOpenAlex for { <https://semopenalex.org/work/W4235544384> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4235544384 endingPage "403" @default.
- W4235544384 startingPage "402" @default.
- W4235544384 abstract "The misfolding and accumulation of the protein fragment β-amyloid (Aβ) is an early and essential event in the pathogenesis of Alzheimer's disease (AD). Despite close biological similarities among primates, humans appear to be uniquely susceptible to the profound neurodegeneration and dementia that characterize AD, even though nonhuman primates deposit copious Aβ in senile plaques and cerebral amyloid-β angiopathy as they grow old. Because the amino acid sequence of Aβ is identical in all primates studied to date, we asked whether differences in the properties of aggregated Aβ might underlie the vulnerability of humans and the resistance of other primates to AD. In a comparison of aged squirrel monkeys (Saimiri sciureus) and humans with AD, immunochemical and mass spectrometric analyses indicate that the populations of Aβ fragments are largely similar in the 2 species. In addition, Aβ-rich brain extracts from the brains of aged squirrel monkeys and AD patients similarly seed the deposition of Aβ in a transgenic mouse model. However, the epitope exposure of aggregated Aβ differs in sodium dodecyl sulfate-stable oligomeric Aβ from the 2 species. In addition, the high-affinity binding of 3H Pittsburgh Compound B to Aβ is significantly diminished in tissue extracts from squirrel monkeys compared with AD patients. These findings support the hypothesis that differences in the pathobiology of aggregated Aβ among primates are linked to post-translational attributes of the misfolded protein, such as molecular conformation and/or the involvement of species-specific cofactors." @default.
- W4235544384 created "2022-05-12" @default.
- W4235544384 date "1967-12-01" @default.
- W4235544384 modified "2023-09-26" @default.
- W4235544384 title "Subject index" @default.
- W4235544384 doi "https://doi.org/10.1016/0014-4800(67)90051-2" @default.
- W4235544384 hasPublicationYear "1967" @default.
- W4235544384 type Work @default.
- W4235544384 citedByCount "0" @default.
- W4235544384 crossrefType "journal-article" @default.
- W4235544384 hasConcept C142724271 @default.
- W4235544384 hasConcept C169760540 @default.
- W4235544384 hasConcept C203014093 @default.
- W4235544384 hasConcept C2776030879 @default.
- W4235544384 hasConcept C2776925932 @default.
- W4235544384 hasConcept C2777633098 @default.
- W4235544384 hasConcept C2777790613 @default.
- W4235544384 hasConcept C2779134260 @default.
- W4235544384 hasConcept C2779483572 @default.
- W4235544384 hasConcept C2780942790 @default.
- W4235544384 hasConcept C502032728 @default.
- W4235544384 hasConcept C59822182 @default.
- W4235544384 hasConcept C68026918 @default.
- W4235544384 hasConcept C71924100 @default.
- W4235544384 hasConcept C86803240 @default.
- W4235544384 hasConceptScore W4235544384C142724271 @default.
- W4235544384 hasConceptScore W4235544384C169760540 @default.
- W4235544384 hasConceptScore W4235544384C203014093 @default.
- W4235544384 hasConceptScore W4235544384C2776030879 @default.
- W4235544384 hasConceptScore W4235544384C2776925932 @default.
- W4235544384 hasConceptScore W4235544384C2777633098 @default.
- W4235544384 hasConceptScore W4235544384C2777790613 @default.
- W4235544384 hasConceptScore W4235544384C2779134260 @default.
- W4235544384 hasConceptScore W4235544384C2779483572 @default.
- W4235544384 hasConceptScore W4235544384C2780942790 @default.
- W4235544384 hasConceptScore W4235544384C502032728 @default.
- W4235544384 hasConceptScore W4235544384C59822182 @default.
- W4235544384 hasConceptScore W4235544384C68026918 @default.
- W4235544384 hasConceptScore W4235544384C71924100 @default.
- W4235544384 hasConceptScore W4235544384C86803240 @default.
- W4235544384 hasIssue "3" @default.
- W4235544384 hasLocation W42355443841 @default.
- W4235544384 hasOpenAccess W4235544384 @default.
- W4235544384 hasPrimaryLocation W42355443841 @default.
- W4235544384 hasRelatedWork W1990161226 @default.
- W4235544384 hasRelatedWork W2003547931 @default.
- W4235544384 hasRelatedWork W2031447310 @default.
- W4235544384 hasRelatedWork W2072554237 @default.
- W4235544384 hasRelatedWork W2116848449 @default.
- W4235544384 hasRelatedWork W2178391263 @default.
- W4235544384 hasRelatedWork W2336965499 @default.
- W4235544384 hasRelatedWork W2345680808 @default.
- W4235544384 hasRelatedWork W2408102490 @default.
- W4235544384 hasRelatedWork W8970903 @default.
- W4235544384 hasVolume "7" @default.
- W4235544384 isParatext "false" @default.
- W4235544384 isRetracted "false" @default.
- W4235544384 workType "article" @default.