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- W4235571857 abstract "Since its discovery in 1988,25 hepatitis C virus (HCV) has emerged as a major cause of chronic liver disease worldwide. The widespread endemicity of HCV infection is the result of a combination of factors, including those related to the genetic diversity of the virus and the host response, and specific settings and behaviors that facilitated transmission. The vast majority of persons who contract HCV infection become persistently infected, and most also develop chronic liver disease, including cirrhosis and hepatocellular carcinoma. The mechanism by which such a high rate of persistent infection is established appears to be related to the lack of development of an effective neutralizing immune response. Like other RNA viruses, the substantial heterogeneity of the HCV genome is the result of mutations that occur during viral replication.19 Within an infected individual, the genetic heterogeneity of HCV consists of a population of closely related, yet heterogeneous, sequences called quasispecies, which result from the rapid development of mutations in a hypervariable region (HVR1) within one of the envelope proteins. Patients infected with HCV mount a humoral immune response to epitopes of HVR1, but sequential changes in the consensus sequence of HVR1 during infection result in the generation of variants that are not recognized by preexisting antibodies.19, 38, 39, 83 The generation of these neutralization escape mutants appears to be the mechanism by which the virus establishes and maintains persistent infection. Although virus- and host-specific factors are responsible for the high rate of chronic HCV infection, the magnitude of the spread of HCV infection is primarily the result of specific factors related to transmission. Historically, healthcare-related factors that have been important in the transmission of HCV included the transfusion of contaminated blood and blood products and the reuse or sharing of contaminated equipment during the course of both traditional and nontraditional medical procedures. The most important human behavior related to the transmission of HCV has been injection drug use, which in many developed countries has been the leading source of HCV infection during the past 20 to 30 years. The clinical importance of HCV infection was recognized only recently, and attention and resources have been rapidly directed toward developing new and improved therapies. The perception of the public health importance of HCV infection is still limited. Despite the knowledge that injection drug use is the major source of HCV infection in the United States, this message has not been included in prevention and treatment programs, and the resources needed to support strong public health programs have yet to be identified." @default.
- W4235571857 created "2022-05-12" @default.
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- W4235571857 date "1998-03-01" @default.
- W4235571857 modified "2023-10-17" @default.
- W4235571857 title "HEPATITIS C" @default.
- W4235571857 cites W1615493023 @default.
- W4235571857 cites W1902746983 @default.
- W4235571857 cites W1956481384 @default.
- W4235571857 cites W1963958655 @default.
- W4235571857 cites W1972208581 @default.
- W4235571857 cites W1974879228 @default.
- W4235571857 cites W1989321942 @default.
- W4235571857 cites W1991378085 @default.
- W4235571857 cites W1993023565 @default.
- W4235571857 cites W1997368021 @default.
- W4235571857 cites W2000229624 @default.
- W4235571857 cites W2004651002 @default.
- W4235571857 cites W2005593320 @default.
- W4235571857 cites W2005641713 @default.
- W4235571857 cites W2005937502 @default.
- W4235571857 cites W2006309458 @default.
- W4235571857 cites W2016111167 @default.
- W4235571857 cites W2024871385 @default.
- W4235571857 cites W2029325114 @default.
- W4235571857 cites W2035254749 @default.
- W4235571857 cites W2035655657 @default.
- W4235571857 cites W2036995945 @default.
- W4235571857 cites W2038449539 @default.
- W4235571857 cites W2047220299 @default.
- W4235571857 cites W2047766116 @default.
- W4235571857 cites W2048408735 @default.
- W4235571857 cites W2056674992 @default.
- W4235571857 cites W2057186427 @default.
- W4235571857 cites W2063142939 @default.
- W4235571857 cites W2066124462 @default.
- W4235571857 cites W2069633422 @default.
- W4235571857 cites W2079377965 @default.
- W4235571857 cites W2080168089 @default.
- W4235571857 cites W2082886348 @default.
- W4235571857 cites W2082941210 @default.
- W4235571857 cites W2085536840 @default.
- W4235571857 cites W2087924794 @default.
- W4235571857 cites W2088053309 @default.
- W4235571857 cites W2090642346 @default.
- W4235571857 cites W2100028901 @default.
- W4235571857 cites W2100572023 @default.
- W4235571857 cites W2108878024 @default.
- W4235571857 cites W2110816492 @default.
- W4235571857 cites W2124352443 @default.
- W4235571857 cites W2124774996 @default.
- W4235571857 cites W2132290252 @default.
- W4235571857 cites W2136774502 @default.
- W4235571857 cites W2150102564 @default.
- W4235571857 cites W2153565848 @default.
- W4235571857 cites W2153970180 @default.
- W4235571857 cites W2161172947 @default.
- W4235571857 cites W22122639 @default.
- W4235571857 cites W2318639814 @default.
- W4235571857 cites W2319055243 @default.
- W4235571857 cites W2323584920 @default.
- W4235571857 cites W2325474665 @default.
- W4235571857 cites W2328171401 @default.
- W4235571857 cites W2331780769 @default.
- W4235571857 cites W2335968781 @default.
- W4235571857 cites W2335969006 @default.
- W4235571857 cites W2338481731 @default.
- W4235571857 cites W2341616068 @default.
- W4235571857 cites W2437864828 @default.
- W4235571857 cites W2562741232 @default.
- W4235571857 cites W4237216814 @default.
- W4235571857 cites W4238194901 @default.
- W4235571857 cites W4244898754 @default.
- W4235571857 cites W4246291298 @default.
- W4235571857 cites W4247919341 @default.
- W4235571857 cites W4251822434 @default.
- W4235571857 cites W4252473362 @default.
- W4235571857 cites W4300498803 @default.
- W4235571857 cites W4300820655 @default.
- W4235571857 cites W4322388703 @default.
- W4235571857 doi "https://doi.org/10.1016/s0891-5520(05)70405-0" @default.
- W4235571857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9494826" @default.
- W4235571857 hasPublicationYear "1998" @default.
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