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- W4235628593 abstract "Background: Borderline resectable pancreatic adenocarcinoma (BRPC) remains a challenging surgical problem. Recently, irreversible electroporation (IRE) has shown promise as a safe adjunct to surgical resection in attempts to improve local control. Here we present a case-matched cohort of patients with BRPC undergoing pancreaticoduodenectomy with and without IRE margin enhancement to evaluate local recurrence and survival. Methods: A retrospective cohort analysis was performed on patients with BRPC. Patients who underwent pancreaticoduodenectomy and concurrent IRE (S-IRE) for margin enhancement were compared to a case-matched cohort who underwent pancreaticoduodenectomy alone (SR) based on demographic, tumor staging and resection margin status. Primary outcome measures included disease recurrence and overall survival. Results: Forty-one patients were included from 2013 to 2018, with 21 in the S-IRE group and 20 case-matched in the SR group. Recurrence-free survival was numerically better for the S-IRE group between 6 and 12 months but overall survival equilibrated by two years (26% vs 34%). There was no statistical difference between S-IRE and SR for medial overall survival (17.5 months vs 19 months) or median recurrence-free survival (15 vs 14.1 months). There was, however, a trend towards a decrease in local recurrence in the S-IRE group (29% vs 54%). Conclusion: This study demonstrated trends towards improvements in short-term recurrence-free survival and decreased local recurrence following margin enhancement with IRE. Results demonstrating a difference in overall survival were limited by loss to follow-up and restricted case matching. Ongoing accruement and continued surveillance will build on the promising trends presented here." @default.
- W4235628593 created "2022-05-12" @default.
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- W4235628593 date "2019-03-01" @default.
- W4235628593 modified "2023-10-16" @default.
- W4235628593 title "Pancreaticoduodenectomy with irreversible electroporation (IRE) Margin enhancement for borderline resectable pancreatic cancer" @default.
- W4235628593 doi "https://doi.org/10.1016/j.hpb.2019.03.229" @default.
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