Matches in SemOpenAlex for { <https://semopenalex.org/work/W4235655753> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4235655753 endingPage "1589" @default.
- W4235655753 startingPage "1567" @default.
- W4235655753 abstract "Developments in the domain of non-peptide opioid receptor agonists, beginning from the first evidence of opiate binding to definite receptors, are briefly summarized. The recent achievements are in a more detailed way depicted and discussed.Novel agonists for each of three opioid receptor basic types (δ, κ and μ) are presented with the special emphasis on one-type-selective ligands. Such selective or even specific agonists have been synthesized with a moderate success. Considerably more serious difficulties concern searching for selective ligands for opioid receptor subtypes (μ1, μ2, δ1, δ2, κ1, κ2, κ3) which may be connected with the fact that dissimiliarities observed in vivo result from postbinding processes (signaling). For the large number of opioid receptor ligands, their structural diversity and relative easiness of generating them from combinatorial libraries (not comparable even with that of orphanine receptors) it is justified to consider the plasticity of opioid receptors (μ-receptor especially). This remark, in conjunction with the existence of opioid receptor types and subtypes, may enable to create new drugs with significantly reduced side-effects. The above facts and brand new reports about highly-active opioid agonists possessing no moieties thought to be essential for agonist activity make the need of reevaluation of classical opioid receptor pharmacophore model extremely important. In general, research results suggest that selective agonists of opioid receptors can be found both in morphine type of ligands and new structures like pyrido-acridine derivatives (COMP1) or diphenylmethylpiperazine derivatives (SNC 80). Better understanding of the structural prerequisites of the opioid receptors binding domains will certainly lead to even more potent and more selective ligands in a near future. Keywords: opioid receptor, combinatorial libraries, pyrido-acridine derivatives, non-peptide agonists, morphine-like agonists, protein coupled receptors, mutagenesis strategy, massage-address concept, benzoylhydrazones of naloxon, morphine modifications" @default.
- W4235655753 created "2022-05-12" @default.
- W4235655753 creator A5025358484 @default.
- W4235655753 creator A5059100019 @default.
- W4235655753 date "2002-09-01" @default.
- W4235655753 modified "2023-10-07" @default.
- W4235655753 title "Non-peptide Opioid Receptor Ligands - Recent Advances. Part I - Agonists" @default.
- W4235655753 doi "https://doi.org/10.2174/0929867023369394" @default.
- W4235655753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12171553" @default.
- W4235655753 hasPublicationYear "2002" @default.
- W4235655753 type Work @default.
- W4235655753 citedByCount "21" @default.
- W4235655753 countsByYear W42356557532012 @default.
- W4235655753 countsByYear W42356557532014 @default.
- W4235655753 countsByYear W42356557532015 @default.
- W4235655753 countsByYear W42356557532016 @default.
- W4235655753 countsByYear W42356557532017 @default.
- W4235655753 crossrefType "journal-article" @default.
- W4235655753 hasAuthorship W4235655753A5025358484 @default.
- W4235655753 hasAuthorship W4235655753A5059100019 @default.
- W4235655753 hasConcept C135285700 @default.
- W4235655753 hasConcept C170493617 @default.
- W4235655753 hasConcept C185592680 @default.
- W4235655753 hasConcept C2778938600 @default.
- W4235655753 hasConcept C2779886867 @default.
- W4235655753 hasConcept C2781063702 @default.
- W4235655753 hasConcept C43587935 @default.
- W4235655753 hasConcept C55493867 @default.
- W4235655753 hasConcept C56173144 @default.
- W4235655753 hasConcept C71240020 @default.
- W4235655753 hasConcept C86803240 @default.
- W4235655753 hasConcept C88016717 @default.
- W4235655753 hasConcept C98274493 @default.
- W4235655753 hasConceptScore W4235655753C135285700 @default.
- W4235655753 hasConceptScore W4235655753C170493617 @default.
- W4235655753 hasConceptScore W4235655753C185592680 @default.
- W4235655753 hasConceptScore W4235655753C2778938600 @default.
- W4235655753 hasConceptScore W4235655753C2779886867 @default.
- W4235655753 hasConceptScore W4235655753C2781063702 @default.
- W4235655753 hasConceptScore W4235655753C43587935 @default.
- W4235655753 hasConceptScore W4235655753C55493867 @default.
- W4235655753 hasConceptScore W4235655753C56173144 @default.
- W4235655753 hasConceptScore W4235655753C71240020 @default.
- W4235655753 hasConceptScore W4235655753C86803240 @default.
- W4235655753 hasConceptScore W4235655753C88016717 @default.
- W4235655753 hasConceptScore W4235655753C98274493 @default.
- W4235655753 hasIssue "17" @default.
- W4235655753 hasLocation W42356557531 @default.
- W4235655753 hasLocation W42356557532 @default.
- W4235655753 hasOpenAccess W4235655753 @default.
- W4235655753 hasPrimaryLocation W42356557531 @default.
- W4235655753 hasRelatedWork W1986341934 @default.
- W4235655753 hasRelatedWork W2013049584 @default.
- W4235655753 hasRelatedWork W2021722027 @default.
- W4235655753 hasRelatedWork W2075796864 @default.
- W4235655753 hasRelatedWork W2130619870 @default.
- W4235655753 hasRelatedWork W2561886516 @default.
- W4235655753 hasRelatedWork W2794568828 @default.
- W4235655753 hasRelatedWork W2811177568 @default.
- W4235655753 hasRelatedWork W3016345108 @default.
- W4235655753 hasRelatedWork W3146713902 @default.
- W4235655753 hasVolume "9" @default.
- W4235655753 isParatext "false" @default.
- W4235655753 isRetracted "false" @default.
- W4235655753 workType "article" @default.