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- W4235691505 abstract "This chapter demonstrates the application of energy and mass transport principles to both the dosage form mechanism of release and the manufacturing process for a novel pharmaceutical formulation. It focuses on an osmotic rupturing multiparticulate formulation manufactured by fluid bed coating. The chapter introduces the formulation and its mechanism of release in order to understand the critical product attributes. It discusses the fluid bed coating process from a general perspective. The chapter shows a physical model for the mechanism of release from rupturing multiparticulates. The primary process used to manufacture the rupturing multiparticulates is Wurster fluid bed coating. The key to developing a successful novel dosage form from a processing perspective is understanding the underlying mechanism of release of the dosage form, the unit operations used in the process, and how the key process variables impact the product properties." @default.
- W4235691505 created "2022-05-12" @default.
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- W4235691505 date "2019-03-29" @default.
- W4235691505 modified "2023-10-16" @default.
- W4235691505 title "PROCESS DESIGN AND DEVELOPMENT FOR NOVEL PHARMACEUTICAL DOSAGE FORMS" @default.
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- W4235691505 doi "https://doi.org/10.1002/9781119600800.ch66" @default.
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