FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4235732004> ?p ?o ?g. }

• W4235732004 endingPage "165" @default.
• W4235732004 startingPage "159" @default.
• W4235732004 abstract "We investigated the effect of thiopental, midazolam, and ketamine (at clinically relevant concentrations and at 0.1 and 10 times these concentrations) on several aspects of human neutrophil functions. The three intravenous (IV) anesthetics significantly decreased chemotaxis, phagocytosis, and reactive oxygen species (ROS) (O2-, H2 O2, OH) production of neutrophils in a dose-dependent manner. At clinically relevant concentrations, thiopental and midazolam significantly depressed these neutrophil functions. However, ketamine at the clinical plasma concentration did not impair chemotaxis or ROS production, except phagocytosis. In contrast, the three anesthetics had no effect on the levels of ROS production by a cell-free ROS generating system. In addition, intracellular calcium concentrations in neutrophils stimulated by N-formyl-L-methionyl-L-leucil-L-phenylalanine were dose-dependently decreased in the presence of each of the three anesthetics. The suppression of an increase in intracellular calcium concentrations may be responsible for the inhibition of neutrophil functions by the IV anesthetics. Implications: Neutrophils play an important role in the antibacterial host defense system and autotissue injury. We found that thiopental and midazolam (but not ketamine), at clinically relevant concentrations, impaired the neutrophil functions." @default.
• W4235732004 created "2022-05-12" @default.
• W4235732004 creator A5006309305 @default.
• W4235732004 creator A5009153839 @default.
• W4235732004 creator A5025861451 @default.
• W4235732004 creator A5062351179 @default.
• W4235732004 creator A5064737618 @default.
• W4235732004 creator A5078738982 @default.
• W4235732004 creator A5086749142 @default.
• W4235732004 date "1998-01-01" @default.
• W4235732004 modified "2023-10-18" @default.
• W4235732004 title "The Inhibitory Effects of Thiopental, Midazolam, and Ketamine on Human Neutrophil Functions" @default.
• W4235732004 cites W1590052573 @default.
• W4235732004 cites W1957020011 @default.
• W4235732004 cites W1966728084 @default.
• W4235732004 cites W1973802695 @default.
• W4235732004 cites W1977610865 @default.
• W4235732004 cites W1978484768 @default.
• W4235732004 cites W1995966677 @default.
• W4235732004 cites W1997236405 @default.
• W4235732004 cites W2023827096 @default.
• W4235732004 cites W2047457444 @default.
• W4235732004 cites W2054817051 @default.
• W4235732004 cites W2063794137 @default.
• W4235732004 cites W2064614184 @default.
• W4235732004 cites W2080217156 @default.
• W4235732004 cites W2093760413 @default.
• W4235732004 cites W2094855729 @default.
• W4235732004 cites W2115942554 @default.
• W4235732004 cites W2117610339 @default.
• W4235732004 cites W2141260882 @default.
• W4235732004 cites W2145646049 @default.
• W4235732004 cites W2150866641 @default.
• W4235732004 cites W2152311269 @default.
• W4235732004 cites W2167935882 @default.
• W4235732004 cites W2424580881 @default.
• W4235732004 doi "https://doi.org/10.1213/00000539-199801000-00032" @default.
• W4235732004 hasPublicationYear "1998" @default.
• W4235732004 type Work @default.
• W4235732004 citedByCount "81" @default.
• W4235732004 countsByYear W42357320042012 @default.
• W4235732004 countsByYear W42357320042013 @default.
• W4235732004 countsByYear W42357320042014 @default.
• W4235732004 countsByYear W42357320042016 @default.
• W4235732004 countsByYear W42357320042017 @default.
• W4235732004 countsByYear W42357320042018 @default.
• W4235732004 countsByYear W42357320042019 @default.
• W4235732004 countsByYear W42357320042020 @default.
• W4235732004 countsByYear W42357320042021 @default.
• W4235732004 countsByYear W42357320042022 @default.
• W4235732004 countsByYear W42357320042023 @default.
• W4235732004 crossrefType "journal-article" @default.
• W4235732004 hasAuthorship W4235732004A5006309305 @default.
• W4235732004 hasAuthorship W4235732004A5009153839 @default.
• W4235732004 hasAuthorship W4235732004A5025861451 @default.
• W4235732004 hasAuthorship W4235732004A5062351179 @default.
• W4235732004 hasAuthorship W4235732004A5064737618 @default.
• W4235732004 hasAuthorship W4235732004A5078738982 @default.
• W4235732004 hasAuthorship W4235732004A5086749142 @default.
• W4235732004 hasBestOaLocation W42357320041 @default.
• W4235732004 hasConcept C126322002 @default.
• W4235732004 hasConcept C134018914 @default.
• W4235732004 hasConcept C160448771 @default.
• W4235732004 hasConcept C170493617 @default.
• W4235732004 hasConcept C17077164 @default.
• W4235732004 hasConcept C181080969 @default.
• W4235732004 hasConcept C185592680 @default.
• W4235732004 hasConcept C198677920 @default.
• W4235732004 hasConcept C203014093 @default.
• W4235732004 hasConcept C2776277131 @default.
• W4235732004 hasConcept C2776814716 @default.
• W4235732004 hasConcept C2776914184 @default.
• W4235732004 hasConcept C2777983669 @default.
• W4235732004 hasConcept C2778000748 @default.
• W4235732004 hasConcept C2780795376 @default.
• W4235732004 hasConcept C2910962159 @default.
• W4235732004 hasConcept C42219234 @default.
• W4235732004 hasConcept C48349386 @default.
• W4235732004 hasConcept C519063684 @default.
• W4235732004 hasConcept C54166955 @default.
• W4235732004 hasConcept C55493867 @default.
• W4235732004 hasConcept C71924100 @default.
• W4235732004 hasConcept C79879829 @default.
• W4235732004 hasConcept C98274493 @default.
• W4235732004 hasConceptScore W4235732004C126322002 @default.
• W4235732004 hasConceptScore W4235732004C134018914 @default.
• W4235732004 hasConceptScore W4235732004C160448771 @default.
• W4235732004 hasConceptScore W4235732004C170493617 @default.
• W4235732004 hasConceptScore W4235732004C17077164 @default.
• W4235732004 hasConceptScore W4235732004C181080969 @default.
• W4235732004 hasConceptScore W4235732004C185592680 @default.
• W4235732004 hasConceptScore W4235732004C198677920 @default.
• W4235732004 hasConceptScore W4235732004C203014093 @default.
• W4235732004 hasConceptScore W4235732004C2776277131 @default.
• W4235732004 hasConceptScore W4235732004C2776814716 @default.
• W4235732004 hasConceptScore W4235732004C2776914184 @default.
• W4235732004 hasConceptScore W4235732004C2777983669 @default.
• W4235732004 hasConceptScore W4235732004C2778000748 @default.

• next