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- W4235764423 abstract "The thyroid hormone receptors, TRα and TRβ, are ligand-dependent transcription factors that regulate gene expression by recruitment of coactivators and corepressors. These receptors play an important role in normal and malignant cell proliferation. TRs can antagonize ras-dependent proliferation, transformation, and tumorigenesis. Furthermore, expression of TRβ1 in cancer cells retards tumor growth and inhibits invasion, extravasation, lymphangiogenesis, and metastasis formation in euthyroid nude mice. The corepressor NCoR is required for these tumor-suppressor actions of the receptor. When cells are inoculated into hypothyroid hosts, tumor growth is retarded, but metastatic growth is enhanced. Increased malignancy of skin tumors is found in mice lacking TRs, further demonstrating the role of these receptors as inhibitors of tumor progression. TRs have a dual effect on proliferation because they are required for proliferation of normal hepatocytes or keratinocytes and activation and mobilization of skin stem cells while acting as inhibitors of tumor progression." @default.
- W4235764423 created "2022-05-12" @default.
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- W4235764423 date "2021-01-01" @default.
- W4235764423 modified "2023-10-16" @default.
- W4235764423 title "Thyroid Hormone Receptors and their Role in Cell Proliferation and Cancer" @default.
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- W4235764423 doi "https://doi.org/10.1016/b978-0-12-819801-8.00011-9" @default.
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