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- W4235774872 abstract "The optimization of drug doses in acutely ill patients is a difficult and multifactorial process.The correct dose is one that exerts a desired therapeutic effect while producing minimal unde-sirable side effects. Critically ill patients may experience physiologic and pharmacokineticchanges that affect the disposition of medications (e.g., heart failure, renal failure, hepaticfailure, trauma, sepsis, and burns). To optimize doses, the critical care practitioner firstmust evaluate these possible physiologic conditions for their effects on the absorption, distri-bution, metabolism, and excretion of drugs. Other crucial factors to consider include both thecondition being treated and other disease states; drug interactions, tolerance, and penetrationto the site of action; other drug therapies; the therapeutic index of the drug; toxic effects; anddose-response relationships. These factors are discussed in this chapter in a general way, anda more specific examination is provided for cardiotonic drugs and agents for treating hyper-tension, since use of these classes of drugs is prevalent in the SICU setting." @default.
- W4235774872 created "2022-05-12" @default.
- W4235774872 date "2005-08-12" @default.
- W4235774872 modified "2023-10-14" @default.
- W4235774872 title "Anaphylaxis" @default.
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- W4235774872 doi "https://doi.org/10.1201/b14532-56" @default.
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