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- W4235801647 abstract "Introduction: The purpose of the study was to identify dimension of and risk factors for chronic kidney disease (CKD) more than 10 years after pediatric liver transplantation (pLTx) in a large single center cohort. Methods: We retrospectively analyzed all children after pLTx at the University Medical Center Hamburg-Eppendorf with more than 10 years of follow-up at the time of the study. Glomerular filtration rate (cGFR) was calculated non-invasively using the new Schwartz-Formula. Results: 79 children with more than 10 years of follow-up were included in the study. Primary diagnosis were biliary atresia (72%), neonatal hepatitis (9%), chronic cholestatic liver disease (8%), Alagille syndrome (5%) and miscellaneous (6%). Mean age at pLTx was 1.5 years, mean follow-up after pLtx was 13.7 years. Prevalence of CKD with cGFR < 90ml/min/1.73m2 was 29%. One patient had CKD stage 3 and 22 patients CKD stage 2. Patients on cyclosporine had a not significant (p=0.0935) lower GFR than patients on tacrolimus. In comparison to previous published data from our center prevalence of CKD increase in the long term follow-up in contrast to a stabilisation of kidney function in the era of 5 to 10 years of follow up. Conclusion: CKD increases in the long-term after pLTx. In addition to chronic graft dysfunction CKD is the most challenging task for the medical care of children following pLTx. The reasons for CKD mostly remain unclear. Thus, kidney biopsies should be considered at a certain stage of renal impairment." @default.
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- W4235801647 date "2012-11-01" @default.
- W4235801647 modified "2023-10-05" @default.
- W4235801647 title "Chronic Kidney Disease More than 10 Years after Pediatric Liver Transplantation" @default.
- W4235801647 doi "https://doi.org/10.1097/00007890-201211271-02373" @default.
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