FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4235812593> ?p ?o ?g. }

• W4235812593 abstract "Abstract BackgroundThe gut microbiome changes in response to a range of environmental conditions, life events and disease states. Pregnancy is a natural life event that involves major physiological adaptation yet studies of the microbiome in pregnancy are limited and their findings inconsistent. Pregnancy with type 1 diabetes (T1D) is associated with increased maternal and fetal risks but the gut microbiome in this context has not been characterized. By whole metagenome sequencing (WMS) we defined the taxonomic composition and function of the gut bacterial microbiome across 70 pregnancies, 36 in women with T1D. ResultsWomen with and without T1D exhibited compositional and functional changes in the gut microbiome across pregnancy. Profiles in women with T1D were distinct, with an increase in bacteria that produce lipopolysaccharides and a decrease in those that produce short chain fatty acids, especially in the third trimester. In addition, women with T1D had elevated concentrations of fecal calprotectin, a marker of intestinal inflammation, and serum intestinal fatty acid-binding protein (I-FABP), a marker of intestinal epithelial damage.ConclusionsWomen with T1D exhibit a shift towards a more pro-inflammatory gut microbiome during pregnancy, associated with evidence of intestinal inflammation. These changes could contribute to the increased risk of pregnancy complications in women with T1D and are potentially modifiable by dietary means." @default.
• W4235812593 created "2022-05-12" @default.
• W4235812593 creator A5017015446 @default.
• W4235812593 creator A5030622173 @default.
• W4235812593 creator A5031926559 @default.
• W4235812593 creator A5037210063 @default.
• W4235812593 creator A5038366375 @default.
• W4235812593 creator A5039369494 @default.
• W4235812593 creator A5040627699 @default.
• W4235812593 creator A5043335832 @default.
• W4235812593 creator A5049193991 @default.
• W4235812593 creator A5051976300 @default.
• W4235812593 creator A5054704071 @default.
• W4235812593 creator A5057823499 @default.
• W4235812593 creator A5060258548 @default.
• W4235812593 creator A5063079080 @default.
• W4235812593 creator A5066105917 @default.
• W4235812593 creator A5066172248 @default.
• W4235812593 creator A5069938993 @default.
• W4235812593 creator A5071725155 @default.
• W4235812593 creator A5078765519 @default.
• W4235812593 creator A5079159447 @default.
• W4235812593 creator A5084607795 @default.
• W4235812593 creator A5085930420 @default.
• W4235812593 creator A5068492124 @default.
• W4235812593 date "2021-04-07" @default.
• W4235812593 modified "2023-09-27" @default.
• W4235812593 title "Type 1 Diabetes in Pregnancy Is Associated With Distinct Changes in the Composition and Function of the Gut Microbiome" @default.
• W4235812593 doi "https://doi.org/10.21203/rs.3.rs-376289/v1" @default.
• W4235812593 hasPublicationYear "2021" @default.
• W4235812593 type Work @default.
• W4235812593 citedByCount "1" @default.
• W4235812593 countsByYear W42358125932022 @default.
• W4235812593 crossrefType "posted-content" @default.
• W4235812593 hasAuthorship W4235812593A5017015446 @default.
• W4235812593 hasAuthorship W4235812593A5030622173 @default.
• W4235812593 hasAuthorship W4235812593A5031926559 @default.
• W4235812593 hasAuthorship W4235812593A5037210063 @default.
• W4235812593 hasAuthorship W4235812593A5038366375 @default.
• W4235812593 hasAuthorship W4235812593A5039369494 @default.
• W4235812593 hasAuthorship W4235812593A5040627699 @default.
• W4235812593 hasAuthorship W4235812593A5043335832 @default.
• W4235812593 hasAuthorship W4235812593A5049193991 @default.
• W4235812593 hasAuthorship W4235812593A5051976300 @default.
• W4235812593 hasAuthorship W4235812593A5054704071 @default.
• W4235812593 hasAuthorship W4235812593A5057823499 @default.
• W4235812593 hasAuthorship W4235812593A5060258548 @default.
• W4235812593 hasAuthorship W4235812593A5063079080 @default.
• W4235812593 hasAuthorship W4235812593A5066105917 @default.
• W4235812593 hasAuthorship W4235812593A5066172248 @default.
• W4235812593 hasAuthorship W4235812593A5068492124 @default.
• W4235812593 hasAuthorship W4235812593A5069938993 @default.
• W4235812593 hasAuthorship W4235812593A5071725155 @default.
• W4235812593 hasAuthorship W4235812593A5078765519 @default.
• W4235812593 hasAuthorship W4235812593A5079159447 @default.
• W4235812593 hasAuthorship W4235812593A5084607795 @default.
• W4235812593 hasAuthorship W4235812593A5085930420 @default.
• W4235812593 hasBestOaLocation W42358125931 @default.
• W4235812593 hasConcept C126322002 @default.
• W4235812593 hasConcept C134018914 @default.
• W4235812593 hasConcept C143121216 @default.
• W4235812593 hasConcept C151730666 @default.
• W4235812593 hasConcept C203014093 @default.
• W4235812593 hasConcept C2777180221 @default.
• W4235812593 hasConcept C2778260677 @default.
• W4235812593 hasConcept C2778292693 @default.
• W4235812593 hasConcept C2779134260 @default.
• W4235812593 hasConcept C2779234561 @default.
• W4235812593 hasConcept C2779343474 @default.
• W4235812593 hasConcept C2781232474 @default.
• W4235812593 hasConcept C3019978661 @default.
• W4235812593 hasConcept C42407357 @default.
• W4235812593 hasConcept C539455810 @default.
• W4235812593 hasConcept C54355233 @default.
• W4235812593 hasConcept C555293320 @default.
• W4235812593 hasConcept C60644358 @default.
• W4235812593 hasConcept C61716771 @default.
• W4235812593 hasConcept C71924100 @default.
• W4235812593 hasConcept C86803240 @default.
• W4235812593 hasConcept C89423630 @default.
• W4235812593 hasConceptScore W4235812593C126322002 @default.
• W4235812593 hasConceptScore W4235812593C134018914 @default.
• W4235812593 hasConceptScore W4235812593C143121216 @default.
• W4235812593 hasConceptScore W4235812593C151730666 @default.
• W4235812593 hasConceptScore W4235812593C203014093 @default.
• W4235812593 hasConceptScore W4235812593C2777180221 @default.
• W4235812593 hasConceptScore W4235812593C2778260677 @default.
• W4235812593 hasConceptScore W4235812593C2778292693 @default.
• W4235812593 hasConceptScore W4235812593C2779134260 @default.
• W4235812593 hasConceptScore W4235812593C2779234561 @default.
• W4235812593 hasConceptScore W4235812593C2779343474 @default.
• W4235812593 hasConceptScore W4235812593C2781232474 @default.
• W4235812593 hasConceptScore W4235812593C3019978661 @default.
• W4235812593 hasConceptScore W4235812593C42407357 @default.
• W4235812593 hasConceptScore W4235812593C539455810 @default.
• W4235812593 hasConceptScore W4235812593C54355233 @default.
• W4235812593 hasConceptScore W4235812593C555293320 @default.
• W4235812593 hasConceptScore W4235812593C60644358 @default.
• W4235812593 hasConceptScore W4235812593C61716771 @default.
• W4235812593 hasConceptScore W4235812593C71924100 @default.

• next