Matches in SemOpenAlex for { <https://semopenalex.org/work/W4235819982> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4235819982 abstract "Abstract Background : Lung cancer is one of the most lethal and most prevalent malignant tumors worldwide, and lung squamous cell carcinoma (LUSC) is one of major histological subtypes. Although, numerous biomarkers were found to be associated with prognosis in LUSC, the prediction effect of a single gene biomarker is not sufficient, especially for glycolysis-related genes. Therefore, we aimed to develop a novel glycolysis-related gene signature to predict survival of patients with LUSC. Methods : The mRNA expression files and clinical information of LUSC were obtained from The Cancer Genome Atlas (TCGA) dataset. Results : Based on Gene set enrichment analysis (GSEA), we found 5 glycolysis-related gene sets were significantly enriched in LUSC tissues. Univariate and multivariate Cox proportional regression models were conducted to choose prognostic-related gene signature. Based on Cox proportional regression model, a risk score of three-gene signature (including HKDC1, ALDH7A1, and MDH1) was established to divide patients into high-risk and low-risk subgroups. We found that a risk score of three-gene signature was an independent of prognostic indicator in LUSC using multivariate Cox regression analysis. Additionally, based on the cBioPortal database, the rate of alterations in HKDC1, ALDH7A1, and MDH1 genes were 1.9%, 1.1%, and 5% in LUSC patients, respectively. Conclusion : In conclusion, a glycolysis-based three-gene signature could serve as a novel biomarker in predicting prognosis of patients with LUSC, which provided more gene targets to cure LUSC patients." @default.
- W4235819982 created "2022-05-12" @default.
- W4235819982 creator A5007978843 @default.
- W4235819982 creator A5017947172 @default.
- W4235819982 creator A5036955281 @default.
- W4235819982 creator A5081919454 @default.
- W4235819982 creator A5087825720 @default.
- W4235819982 date "2020-11-09" @default.
- W4235819982 modified "2023-09-28" @default.
- W4235819982 title "A glycolysis-based three-gene signature predicts survival in patients with lung squamous cell carcinoma" @default.
- W4235819982 doi "https://doi.org/10.21203/rs.3.rs-42550/v2" @default.
- W4235819982 hasPublicationYear "2020" @default.
- W4235819982 type Work @default.
- W4235819982 citedByCount "0" @default.
- W4235819982 crossrefType "posted-content" @default.
- W4235819982 hasAuthorship W4235819982A5007978843 @default.
- W4235819982 hasAuthorship W4235819982A5017947172 @default.
- W4235819982 hasAuthorship W4235819982A5036955281 @default.
- W4235819982 hasAuthorship W4235819982A5081919454 @default.
- W4235819982 hasAuthorship W4235819982A5087825720 @default.
- W4235819982 hasBestOaLocation W42358199821 @default.
- W4235819982 hasConcept C104317684 @default.
- W4235819982 hasConcept C10515644 @default.
- W4235819982 hasConcept C105795698 @default.
- W4235819982 hasConcept C126322002 @default.
- W4235819982 hasConcept C143998085 @default.
- W4235819982 hasConcept C150194340 @default.
- W4235819982 hasConcept C161584116 @default.
- W4235819982 hasConcept C18431079 @default.
- W4235819982 hasConcept C199163554 @default.
- W4235819982 hasConcept C2776256026 @default.
- W4235819982 hasConcept C2779733811 @default.
- W4235819982 hasConcept C2781197716 @default.
- W4235819982 hasConcept C33923547 @default.
- W4235819982 hasConcept C502942594 @default.
- W4235819982 hasConcept C50382708 @default.
- W4235819982 hasConcept C54355233 @default.
- W4235819982 hasConcept C71924100 @default.
- W4235819982 hasConcept C86803240 @default.
- W4235819982 hasConceptScore W4235819982C104317684 @default.
- W4235819982 hasConceptScore W4235819982C10515644 @default.
- W4235819982 hasConceptScore W4235819982C105795698 @default.
- W4235819982 hasConceptScore W4235819982C126322002 @default.
- W4235819982 hasConceptScore W4235819982C143998085 @default.
- W4235819982 hasConceptScore W4235819982C150194340 @default.
- W4235819982 hasConceptScore W4235819982C161584116 @default.
- W4235819982 hasConceptScore W4235819982C18431079 @default.
- W4235819982 hasConceptScore W4235819982C199163554 @default.
- W4235819982 hasConceptScore W4235819982C2776256026 @default.
- W4235819982 hasConceptScore W4235819982C2779733811 @default.
- W4235819982 hasConceptScore W4235819982C2781197716 @default.
- W4235819982 hasConceptScore W4235819982C33923547 @default.
- W4235819982 hasConceptScore W4235819982C502942594 @default.
- W4235819982 hasConceptScore W4235819982C50382708 @default.
- W4235819982 hasConceptScore W4235819982C54355233 @default.
- W4235819982 hasConceptScore W4235819982C71924100 @default.
- W4235819982 hasConceptScore W4235819982C86803240 @default.
- W4235819982 hasLocation W42358199821 @default.
- W4235819982 hasLocation W42358199822 @default.
- W4235819982 hasOpenAccess W4235819982 @default.
- W4235819982 hasPrimaryLocation W42358199821 @default.
- W4235819982 hasRelatedWork W13038688 @default.
- W4235819982 hasRelatedWork W13212225 @default.
- W4235819982 hasRelatedWork W13487282 @default.
- W4235819982 hasRelatedWork W13920634 @default.
- W4235819982 hasRelatedWork W3320906 @default.
- W4235819982 hasRelatedWork W3669563 @default.
- W4235819982 hasRelatedWork W5352886 @default.
- W4235819982 hasRelatedWork W6834028 @default.
- W4235819982 hasRelatedWork W9212281 @default.
- W4235819982 hasRelatedWork W2758172 @default.
- W4235819982 isParatext "false" @default.
- W4235819982 isRetracted "false" @default.
- W4235819982 workType "article" @default.