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- W4235861008 abstract "The binding of [ 3 H]substance P (SP) was localized and characterized in canine small intestine. The highest density of [ 3 H]SP binding occurred in the fraction enriched in circular muscle membranes ( B max 148 ± 14 fmol/mg; K d 0.81 ± 0.01 n M ). In the kinetics studies binding was reversible, yielding a similar K d value. NK 1 agonists and antagonists fully displaced, but ligands at the NK 2 and NK 3 receptor only partially displaced, [ 3 H]SP binding. The potency order of displacement resembled that for the human NK 1 receptor ortholog rather than the rat NK 1 receptor. Densities of [ 3 H]SP binding were lower in myenteric plexus and longitudinal muscle membrane fractions, but suggested binding in both neural and muscle membranes. The conclusion is that NK 1 receptors occur primarily in canine intestine circular muscle plasma membrane." @default.
- W4235861008 created "2022-05-12" @default.
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- W4235861008 date "1996-09-03" @default.
- W4235861008 modified "2023-09-30" @default.
- W4235861008 title "Characterization of Neurokinin Type 1 Receptor in Canine Small Intestinal Muscle" @default.
- W4235861008 doi "https://doi.org/10.1016/s0196-9781(96)00084-8" @default.
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