FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4235871007> ?p ?o ?g. }

• W4235871007 abstract "There is a hypothesis that high dose chemotherapy with autologous bone marrow or stem cell transplantation (autograft) may improve survival for women with metastatic breast cancer.To compare the effectiveness of high dose chemotherapy and autologous bone marrow or stem cell transplantation with conventional chemotherapy for women with metastatic breast cancer.We used the Cochrane Breast Cancer Group search strategy, adding these terms: bone marrow transplantation, stem cell transplantation, autologous stem cell support. The following databases were searched: MEDLINE (until August 2002), EMBASE (until July 2002), ASCO (American Society of Clinical Oncology) (1995-2002) and the COCHRANE LIBRARY (Issue 3 2002). We searched the Cochrane Breast Cancer Group database and cooperative research groups' websites for unpublished trials.Randomised controlled trials comparing the effectiveness of high dose chemotherapy and autograft with conventional chemotherapy for women with metastatic breast cancer. Studies included one or more of the following outcomes: treatment related mortality, overall or progression-free survival at 1, 2, 3, 5 or 7 years, morbidity, quality of life measures, time to tumour progression, overall survival time.Five randomised controlled trials met the inclusion criteria. Two independent reviewers extracted data.In total 382 women were randomised to receive high dose chemotherapy with autograft and 358 were randomised to receive conventional treatment. There were ten treatment related deaths among the high dose group and none reported in the control (conventional dose) group (RR 5.70, 95%CI (1.30, 25)). There was no statistically significant difference in overall survival between the high dose and control groups (at one year: RR 0.99, 95% CI (0.91, 1.08); three years: RR 1.16 95% CI (0.90, 1.51); five years: RR 1.28, 95% CI (0.72, 2.27)). At one and two years of follow up, a statistically significant difference in progression free survival was reported, favouring the high dose group (one year: RR 1.81, 95% CI (1.39,2.34); two years: RR 1.96, 95% CI (1.32, 2.90 ). However this difference was not evident at three or five years (three years: RR 1.44, 95% CI (0.85, 2.44); five years: RR 1.21, 95% CI (0.40, 3.69). Toxicity was more severe in the high dose group. None of the trials has completed follow up and further data are awaited.Although there is evidence that high dose chemotherapy and autograft improves progression free survival at one and two years' follow up compared to conventional chemotherapy, there is no evidence of benefit in overall survival." @default.
• W4235871007 created "2022-05-12" @default.
• W4235871007 creator A5009731454 @default.
• W4235871007 creator A5010711854 @default.
• W4235871007 creator A5031445860 @default.
• W4235871007 creator A5078482500 @default.
• W4235871007 creator A5081406633 @default.
• W4235871007 date "2002-10-21" @default.
• W4235871007 modified "2023-09-30" @default.
• W4235871007 title "High dose chemotherapy and autologous bone marrow or stem cell transplantation versus conventional chemotherapy for women with metastatic breast cancer" @default.
• W4235871007 cites W1785581158 @default.
• W4235871007 cites W1896390601 @default.
• W4235871007 cites W1899541887 @default.
• W4235871007 cites W1913826936 @default.
• W4235871007 cites W1917247105 @default.
• W4235871007 cites W1938930090 @default.
• W4235871007 cites W1967612488 @default.
• W4235871007 cites W1973702706 @default.
• W4235871007 cites W1985492920 @default.
• W4235871007 cites W1993130968 @default.
• W4235871007 cites W2010501374 @default.
• W4235871007 cites W2015668657 @default.
• W4235871007 cites W2036335583 @default.
• W4235871007 cites W2041034171 @default.
• W4235871007 cites W2052343019 @default.
• W4235871007 cites W2083616014 @default.
• W4235871007 cites W2106708607 @default.
• W4235871007 cites W2113143479 @default.
• W4235871007 cites W2123927174 @default.
• W4235871007 cites W2220331219 @default.
• W4235871007 cites W2228671601 @default.
• W4235871007 cites W2268597691 @default.
• W4235871007 cites W2273887450 @default.
• W4235871007 cites W2276085691 @default.
• W4235871007 cites W2917106067 @default.
• W4235871007 cites W82109857 @default.
• W4235871007 doi "https://doi.org/10.1002/14651858.cd003142" @default.
• W4235871007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12535458" @default.
• W4235871007 hasPublicationYear "2002" @default.
• W4235871007 type Work @default.
• W4235871007 citedByCount "2" @default.
• W4235871007 crossrefType "reference-entry" @default.
• W4235871007 hasAuthorship W4235871007A5009731454 @default.
• W4235871007 hasAuthorship W4235871007A5010711854 @default.
• W4235871007 hasAuthorship W4235871007A5031445860 @default.
• W4235871007 hasAuthorship W4235871007A5078482500 @default.
• W4235871007 hasAuthorship W4235871007A5081406633 @default.
• W4235871007 hasConcept C121608353 @default.
• W4235871007 hasConcept C126322002 @default.
• W4235871007 hasConcept C141071460 @default.
• W4235871007 hasConcept C143998085 @default.
• W4235871007 hasConcept C168563851 @default.
• W4235871007 hasConcept C2775930923 @default.
• W4235871007 hasConcept C2776478404 @default.
• W4235871007 hasConcept C2776694085 @default.
• W4235871007 hasConcept C2779050716 @default.
• W4235871007 hasConcept C2911091166 @default.
• W4235871007 hasConcept C530470458 @default.
• W4235871007 hasConcept C71924100 @default.
• W4235871007 hasConceptScore W4235871007C121608353 @default.
• W4235871007 hasConceptScore W4235871007C126322002 @default.
• W4235871007 hasConceptScore W4235871007C141071460 @default.
• W4235871007 hasConceptScore W4235871007C143998085 @default.
• W4235871007 hasConceptScore W4235871007C168563851 @default.
• W4235871007 hasConceptScore W4235871007C2775930923 @default.
• W4235871007 hasConceptScore W4235871007C2776478404 @default.
• W4235871007 hasConceptScore W4235871007C2776694085 @default.
• W4235871007 hasConceptScore W4235871007C2779050716 @default.
• W4235871007 hasConceptScore W4235871007C2911091166 @default.
• W4235871007 hasConceptScore W4235871007C530470458 @default.
• W4235871007 hasConceptScore W4235871007C71924100 @default.
• W4235871007 hasLocation W42358710071 @default.
• W4235871007 hasLocation W42358710072 @default.
• W4235871007 hasOpenAccess W4235871007 @default.
• W4235871007 hasPrimaryLocation W42358710071 @default.
• W4235871007 hasRelatedWork W2041933719 @default.
• W4235871007 hasRelatedWork W2348231456 @default.
• W4235871007 hasRelatedWork W2354050160 @default.
• W4235871007 hasRelatedWork W2367105124 @default.
• W4235871007 hasRelatedWork W2368979736 @default.
• W4235871007 hasRelatedWork W2369039771 @default.
• W4235871007 hasRelatedWork W2379151083 @default.
• W4235871007 hasRelatedWork W2388730008 @default.
• W4235871007 hasRelatedWork W2791179561 @default.
• W4235871007 hasRelatedWork W3181412252 @default.
• W4235871007 isParatext "false" @default.
• W4235871007 isRetracted "false" @default.
• W4235871007 workType "reference-entry" @default.