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- W4235959575 abstract "Abstract Background: CDKN2A hypermethylation is among of the major events associated with carcinogenesis and is also observed in non-neoplastic colonic mucosa in patients with ulcerative colitis (UC). Macrophage migration inhibitory factor (MIF) plays a crucial role in promoting gastrointestinal inflammation characteristic of UC. The aim of this study is to explore associations between CDKN2A methylation status and MIF polymorphisms (rs755622 and rs5844572). Methods: One hundred and fifty-nine patients diagnosed with UC were enrolled in this study. The methylation status of p14 ARF and p16 INK4a was determined by MSP; MIF genotypes were identified by PCR-SSCP. Results: The frequencies of the rs755662 GC + CC genotype and rs5844572 7-repeat allele were significantly higher in group with methylated p14 ARF and methylated p16 INK4a , respectively. Carrying the rs755622 C allele indicated a significantly higher risk for p14 ARF methylation (odds ratio (OR), 2.16; 95% confidence interval (CI), 1.08-4.32); similarly, carrying the rs5844572 7-repeat allele indicated a significantly higher risk for p16 INK4a methylation (OR, 2.57; 95% CI, 1.26–5.24) after an adjusted regression analysis. The carriers of the rs755662 C allele and the rs5844572 7-repeat allele were both at a significantly higher risk for methylation of both p14 ARF and p16 INK4a when compared to the cohort in which neither of the genes were methylated (OR, 2.70; 95% CI, 1.22–6.01 and OR, 2.87; 95% CI, 1.25–6.62, respectively). Conclusions: Taken together, our findings suggest that MIF genotypes associated with inflammation may also be involved in promoting carcinogenesis via CDKN2A hyper-methylation in patients diagnosed with UC." @default.
- W4235959575 created "2022-05-12" @default.
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- W4235959575 date "2020-08-24" @default.
- W4235959575 modified "2023-09-26" @default.
- W4235959575 title "Influence of MIF Polymorphisms on CpG Island Hyper-methylation of CDKN2A in the Patients With Ulcerative Colitis" @default.
- W4235959575 doi "https://doi.org/10.21203/rs.3.rs-57255/v1" @default.
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