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- W4235961435 abstract "We appreciate Dr Augoustides’ kind comments regarding our article.1Sedrakayan A. Wu A. Sedrakayan G. et al.Aprotinin use in thoracic aortic surgery: safety and outcomes.J Thorac Cardiovasc Surg. 2006; 132: 909-917Abstract Full Text Full Text PDF PubMed Scopus (29) Google Scholar We are very much aware of the important contributions he and his colleagues have made on the topic at hand. We provide the following specific responses to the insightful comments and questions raised in Dr. Augoustides’ letter.1Three patients required reexploration for bleeding—1 in the aprotinin group and 2 in the control group.2Anesthesia was by a balanced narcotic/inhalation technique in both groups.3Renal failure occurred in 3 patients in the control group and 2 in the aprotinin group.4Aprotinin was administered after the skin incision. It is our policy to avoid aprotinin in the rare circumstance of recent prior aprotinin exposure.5There were no clinically appreciated hypersensitivity reactions to aprotinin. There were no cases of unexpected vascular thrombosis.In sum, the points raised by Dr Augoustides are all very cogent. On each point, there was, in our study, no evidence of adverse aprotinin-related outcome. Limitations with aprotinin in thoracic aortic surgery: Understanding the clinical outcome beyond bleedingThe Journal of Thoracic and Cardiovascular SurgeryVol. 134Issue 1PreviewI read with great interest the recent article by Dr Sedrakyan and colleagues1 detailing their experience with aprotinin in thoracic aortic surgery, using a retrospective case-control matching analysis (n = 168 [1995-2003]: deep hypothermic circulatory arrest (DHCA) 64.3%–67.9%). The authors conclude in their article that there is American Heart Association level II evidence for aprotinin in thoracic aortic surgery. Full-Text PDF" @default.
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- W4235961435 date "2007-07-01" @default.
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- W4235961435 title "Reply to the Editor" @default.
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- W4235961435 doi "https://doi.org/10.1016/j.jtcvs.2007.01.027" @default.
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