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- W4235986911 abstract "The human skin microbiome has important roles in skin health and disease. However, bacterial population structure and diversity at the strain level is poorly understood. We compared the skin microbiome at the strain level and genome level of Propionibacterium acnes, a dominant skin commensal, between 49 acne patients and 52 healthy individuals by sampling the pilosebaceous units on their noses. Metagenomic analysis demonstrated that although the relative abundances of P. acnes were similar, the strain population structures were significantly different in the two cohorts. Certain strains were highly associated with acne, and other strains were enriched in healthy skin. By sequencing 66 previously unreported P. acnes strains and comparing 71 P. acnes genomes, we identified potential genetic determinants of various P. acnes strains in association with acne or health. Our analysis suggests that acquired DNA sequences and bacterial immune elements may have roles in determining virulence properties of P. acnes strains, and some could be future targets for therapeutic interventions. This study demonstrates a previously unreported paradigm of commensal strain populations that could explain the pathogenesis of human diseases. It underscores the importance of strain-level analysis of the human microbiome to define the role of commensals in health and disease. PMID: 23337890 Funding information This work was supported by: NIAMS NIH HHS, United States Grant ID: UH2 AR057503 NHGRI NIH HHS, United States Grant ID: U54HG004968 NHGRI NIH HHS, United States Grant ID: U54 HG004968 NCATS NIH HHS, United States Grant ID: UL1 TR000124 NIAMS NIH HHS, United States Grant ID: UH2AR057503" @default.
- W4235986911 created "2022-05-12" @default.
- W4235986911 creator A5083271506 @default.
- W4235986911 date "2013-07-12" @default.
- W4235986911 modified "2023-09-27" @default.
- W4235986911 title "Faculty Opinions recommendation of Propionibacterium acnes strain populations in the human skin microbiome associated with acne." @default.
- W4235986911 doi "https://doi.org/10.3410/f.717972822.793480127" @default.
- W4235986911 hasPublicationYear "2013" @default.
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