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- W4236016302 abstract "There is a tradition in Germany, to nominate at the beginning of a year, the “Unwort des Jahres” – best translated into English as ‘the worst word’ or the ‘bad word’ of the year” for the previous year. The “worst word” of 2017 was “alternative Fakten”, which needs no translation I assume. It hardly needs saying that alternative facts are in direct opposition to scientifically well-conducted and presented research work so it is disconcerting that in some regions of the world, facts – and the scientific method – are now under attack, often replaced with belief and conviction. Scientific research is challenged because it carries negative financial consequences, like reduced funding for example. This very substantial, if not better to call dramatic, change is also noted by editorials in publications like Scientific American last October 1 and in Nature 2. As a notable consequence, other countries are on their marks to fill this vacuum. In 2016, China's research output surpassed that of the US, and publications from developing countries are growing faster than those of the developed world. In the long term, if the trends continue, the center of research productivity will move to other parts of the globe 3. Obviously, we at Cytometry Part A, like others, are noticing an increase in submission numbers and improved quality from Asian countries, particularly from China 4, whose ambition is become a leader in science, an ambition backed up by enviable funding. We have commented on these developments earlier in Cytometry Part A 4, 5. Consequently, I selected for this month's Editors’ Choice the manuscript of Zhao and You (this issue, page 222) from Tsinghua University in Beijing. Cell sorting in microfluidic cytometry can be done in a “global” manner based on morphological characteristics such as cell size and shape and performed by elegant structures within the microfluidic device 6 or can alternatively be cell specific, as in the present report. Zhao and You present an innovative microfluidic sorting method for cells that relies on microbubble formation generated by sparks to move cytometrically identified cells into the sorting channel. As the authors emphasize, this approach is a good alternative to other bubble generating sorting methods in microfluidic cytometry (see also their interesting microfluidic design). Picking up the above mentioned “unword”: seeing is believing. I had the pleasure to visit the lab of Zheng You to get a real-world demonstration of the instrument and sorting that they report of now. This is one out of the two publications from China in this month. The second is from Zhang and colleagues (this issue, page 213) on an interesting flow cytometric approach to characterize and sort different types of maize starch. The method has practical applications and consequences for the crop industry. I also wanted to draw your attention to two reports on the analysis of bacterial communities. First, the work presented by Amalfitano and colleagues (this issue, page 194); this article is also commented upon by Corno and Calleri in this issue (page 180). And second, the work by Buysschaert and colleagues (this issue, page 201). Both manuscripts address the question on how to comprehensively and reproducibly analyze and interpret complex microbial populations and strains. In combination with approaches for optimized instrument setup for the analysis of microbial populations 7, better understanding of complex microbial ecosystems and strain relations is available. Also the OMIP family is growing. Here, you will find three new OMIPs on Rat Microglia, Antibody Secreting Cells and a 21-color panel on human PBLs (this issue, pages 182, 186, 190, respectively). I'm looking forward to the first OMIPs on bacterial communities." @default.
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- W4236016302 date "2018-02-01" @default.
- W4236016302 modified "2023-09-23" @default.
- W4236016302 title "Alternatives" @default.
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- W4236016302 doi "https://doi.org/10.1002/cyto.a.23335" @default.
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