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- W4236020329 abstract "The need for improved Alzheimer's disease therapies is unmet. 5-HT 4 receptor may play a role in memory and learning. Activation of 5-HT 4 receptors has been reported to modulate acetylcholine release and reduce beta amyloid accumulation. It is postulated that activation of 5-HT 4 receptors will offer improved clinical efficacy and/or tolerability relative to acetylcholine esterase inhibitors. 5-HT 4 receptor partial agonists may be of benefit for both the symptomatic and disease-modifying treatment of cognitive disorders. SUVN-D1104010 a potent and selective 5-HT 4 receptor partial agonist was evaluated for its procognitive property in object recognition task and radial arm maze task using rats. Modulation of acetylcholine levels by SUVN-D1104010 was evaluated using brain microdialysis technique. SUVN-D1104010 reversed the episodic memory deficits in object recognition task and working memory deficits induced by scopolamine in radial arm maze task. Oral administration of SUVN-D1104010 significantly increased the brain acetylcholine levels. The effect observed was blocked by a selective 5-HT 4 antagonist. SUVN-D1104010 is a potent, selective, orally bioavailable and efficacious 5-HT 4 receptor partial agonist that holds promise for the management of the hallmark symptomatologies observed in Alzheimer's disease." @default.
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- W4236020329 date "2012-07-01" @default.
- W4236020329 modified "2023-10-16" @default.
- W4236020329 title "P2-389: SUVN-D1104010: Novel 5-HT4 receptor partial agonist for the treatment of Alzheimer's disease" @default.
- W4236020329 doi "https://doi.org/10.1016/j.jalz.2012.05.1099" @default.
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