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- W4236024644 abstract "Increasingly cancer is being viewed as a channelopathy because the passage of ions via ion channels and transporters mediate the regulation of tumor cell survival, death, and motility. As a result, a potential targeted therapy for cancer is to use venom peptides that are selective for ion channels and transporters overexpressed in tumor cells. Here we describe the selectivity and mechanism of action of terebrid snail venom peptide, Tv1, for treating the most common type of liver cancer, hepatocellular carcinoma (HCC). Tv1 inhibited the proliferation of murine HCC cells and significantly reduced tumor size in Tv1-treated syngeneic tumor-bearing mice. Tv1's mechanism of action involves binding to overexpressed transient receptor potential (TRP) channels leading to calcium dependent apoptosis resulting from down-regulation of cyclooxygenase-2 (COX-2). Our findings demonstrate the importance of modulating ion channels and the unique potential of venom peptides as tumor specific ligands in the quest for targeted cancer therapies. PMID: 31627357" @default.
- W4236024644 created "2022-05-12" @default.
- W4236024644 creator A5053503288 @default.
- W4236024644 date "2020-12-16" @default.
- W4236024644 modified "2023-09-28" @default.
- W4236024644 title "Faculty Opinions recommendation of Selective inhibition of liver cancer cells using venom peptide." @default.
- W4236024644 doi "https://doi.org/10.3410/f.736781114.793581212" @default.
- W4236024644 hasPublicationYear "2020" @default.
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