FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236025443> ?p ?o ?g. }

• W4236025443 endingPage "e162" @default.
• W4236025443 startingPage "e162" @default.
• W4236025443 abstract "To the Editor: We appreciate the letter to the editor authored by Drs. Joob and Wiwanitkit comparing interferon-gamma release assays (IGRAs) to the tuberculin skin test (TST). The best measure of a screening tool is its sensitivity, and the IGRA sensitivity in our study was 83%. Its negative predictive value, moreover, was 99.9%. Multiple pediatric studies with a larger number of patients positive for tuberculosis have demonstrated IGRAs to have a higher sensitivity than TST (1,2). TSTs suffer from the subjectivity of the individual interpreting the skin reaction. Patients who are immunosuppressed and children under 4 years old are less likely to have a robust reaction to TST, and the traditional criteria of 15 mm induration can have a sensitivity of less than 70% (3). The positive predictive value of IGRs is not reflective of its utility as a screening test given the relatively low prevalence of LTBI. Our 4 false-positive results over a 7-year period were easily clarified by repeat IGRA testing that was negative. TST can have a high false-positive rate in patients who have received the Bacille Calmette-Guérin vaccine, and patients who have been infected with nontuberculous mycobacterial infections. Importantly, we found that prior TST results are inconsistently and poorly documented in the results section of electronic health records (EHRs) compared with IGRA, and if found in notes rarely specify the size of induration. This is significant in the era of electronic health records whereby retrieving results is an important feature and results need to be retrieved by treating providers, infusion centers, case managers, and nurses. Although IGRA serology testing has a slightly higher laboratory cost, TST has higher costs associated with nursing administration and reading. They require 2 clinic visits, assuming patient compliance, and sometimes 4 visits to increase sensitivity for older infections via “2-step testing.” There are additional unmeasured costs to the patient through missed time at school or work, transportation, etc. In a recent study, IGRAs were found to be more cost-effective than TST in healthcare workers (4). We suggest that screening IBD patients is similar to screening healthcare workers, and many of the previous studies evaluating cost effectiveness used immigrants or close contacts to known TB patients, which are much different patient populations than IBD patients. We recognize that IGRA testing is not readily accessible in all clinics throughout the world. In these cases, TST can be an effective screening tool, and should be used for routine screening in pediatric patients with IBD receiving anti-tumor necrosis factor (TNF) alpha therapy. However, we suggest that if IGRA testing is available it should be considered as a replacement to TST because of its cost-effectiveness and ease of retrieving in the electronic health records." @default.
• W4236025443 created "2022-05-12" @default.
• W4236025443 creator A5007781462 @default.
• W4236025443 creator A5012091052 @default.
• W4236025443 creator A5069910335 @default.
• W4236025443 creator A5081732961 @default.
• W4236025443 creator A5086034125 @default.
• W4236025443 creator A5087331757 @default.
• W4236025443 creator A5089529757 @default.
• W4236025443 date "2019-12-01" @default.
• W4236025443 modified "2023-09-26" @default.
• W4236025443 title "Performance of Interferon-gamma Release Assays for Tuberculosis Screening in Pediatric Inflammatory Bowel Disease" @default.
• W4236025443 cites W1974006717 @default.
• W4236025443 cites W2105163700 @default.
• W4236025443 cites W2529847803 @default.
• W4236025443 cites W2802940803 @default.
• W4236025443 doi "https://doi.org/10.1097/mpg.0000000000002501" @default.
• W4236025443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31568149" @default.
• W4236025443 hasPublicationYear "2019" @default.
• W4236025443 type Work @default.
• W4236025443 citedByCount "3" @default.
• W4236025443 countsByYear W42360254432019 @default.
• W4236025443 countsByYear W42360254432020 @default.
• W4236025443 countsByYear W42360254432022 @default.
• W4236025443 crossrefType "journal-article" @default.
• W4236025443 hasAuthorship W4236025443A5007781462 @default.
• W4236025443 hasAuthorship W4236025443A5012091052 @default.
• W4236025443 hasAuthorship W4236025443A5069910335 @default.
• W4236025443 hasAuthorship W4236025443A5081732961 @default.
• W4236025443 hasAuthorship W4236025443A5086034125 @default.
• W4236025443 hasAuthorship W4236025443A5087331757 @default.
• W4236025443 hasAuthorship W4236025443A5089529757 @default.
• W4236025443 hasBestOaLocation W42360254431 @default.
• W4236025443 hasConcept C126322002 @default.
• W4236025443 hasConcept C142724271 @default.
• W4236025443 hasConcept C195910791 @default.
• W4236025443 hasConcept C203014093 @default.
• W4236025443 hasConcept C2776247216 @default.
• W4236025443 hasConcept C2777975735 @default.
• W4236025443 hasConcept C2779134260 @default.
• W4236025443 hasConcept C2780639635 @default.
• W4236025443 hasConcept C2781069245 @default.
• W4236025443 hasConcept C3019719930 @default.
• W4236025443 hasConcept C71924100 @default.
• W4236025443 hasConceptScore W4236025443C126322002 @default.
• W4236025443 hasConceptScore W4236025443C142724271 @default.
• W4236025443 hasConceptScore W4236025443C195910791 @default.
• W4236025443 hasConceptScore W4236025443C203014093 @default.
• W4236025443 hasConceptScore W4236025443C2776247216 @default.
• W4236025443 hasConceptScore W4236025443C2777975735 @default.
• W4236025443 hasConceptScore W4236025443C2779134260 @default.
• W4236025443 hasConceptScore W4236025443C2780639635 @default.
• W4236025443 hasConceptScore W4236025443C2781069245 @default.
• W4236025443 hasConceptScore W4236025443C3019719930 @default.
• W4236025443 hasConceptScore W4236025443C71924100 @default.
• W4236025443 hasIssue "6" @default.
• W4236025443 hasLocation W42360254431 @default.
• W4236025443 hasLocation W42360254432 @default.
• W4236025443 hasLocation W42360254433 @default.
• W4236025443 hasOpenAccess W4236025443 @default.
• W4236025443 hasPrimaryLocation W42360254431 @default.
• W4236025443 hasRelatedWork W2067756856 @default.
• W4236025443 hasRelatedWork W2079296682 @default.
• W4236025443 hasRelatedWork W2097586979 @default.
• W4236025443 hasRelatedWork W2147495461 @default.
• W4236025443 hasRelatedWork W2151040997 @default.
• W4236025443 hasRelatedWork W2763200999 @default.
• W4236025443 hasRelatedWork W3028963034 @default.
• W4236025443 hasRelatedWork W3036655379 @default.
• W4236025443 hasRelatedWork W747133875 @default.
• W4236025443 hasRelatedWork W97474110 @default.
• W4236025443 hasVolume "69" @default.
• W4236025443 isParatext "false" @default.
• W4236025443 isRetracted "false" @default.
• W4236025443 workType "article" @default.