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- W4236028445 abstract "Summary: Depending on the concentration, endothelin-3 (ET-3) has activating or inhibitory effects on neutrophil migration. At concentrations below 10 nM, neutrophil migration was stimulated by ET-3. The stimulating effect of ET-3 was mainly chemotactic, in contrast with that of ET-1, which was mainly chemokinetic. Concentrations of ET-3 lower than 10 nM potentiated chemotaxis activated by fMet-Leu-Phe (fMLP), whereas concentrations higher than 10 nM inhibited fMLP-activated neutrophil chemo- taxis. The ETA receptor antagonist BQ123, the ET receptor agonist sarafotoxin S6c, and the ETB receptor antagonist IRL 1038 inhibited ET-3-and fMLP-activated migration. All of these compounds reversed the inhibitory effect of high concentrations of ET-3 on fMLP-activated chemotaxis. The results suggest that the ETA and the ETB receptor are both involved in the activating and inhibitory effects of ET-3." @default.
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- W4236028445 date "1995-01-01" @default.
- W4236028445 modified "2023-10-17" @default.
- W4236028445 title "Stimulation and Inhibition of Neutrophil Chemotaxis by Endothelin-3" @default.
- W4236028445 doi "https://doi.org/10.1097/00005344-199526003-00044" @default.
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