FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236028560> ?p ?o ?g. }

• W4236028560 endingPage "266" @default.
• W4236028560 startingPage "249" @default.
• W4236028560 abstract "The delivery of ciliary neurotrophic factor (CNTF) to the central nervous system has recently been proposed as a potential means of halting or slowing the neural degeneration associated with Huntington's disease (HD). The following set of experiments examined, in detail, the ability of human CNTF (hCNTF) to prevent the onset of behavioral dysfunction in a rodent model of HD. A DHFR-based expression vector containing the hCNTF gene was transfected into a baby hamster kidney fibroblast cell line (BHK). Using a polymeric device, encapsulated BHK-control cells and those secreting hCNTF were transplanted bilaterally into rat lateral ventricles. Eight days later, the same animals received bilateral injections of quinolinic acid (QA, 225 nmol) into the previously implanted striata. A third group received sham surgery (incision only) and served as a normal control group. Bilateral infusions of QA produced a significant loss of body weight and mortality that was prevented by prior implantation with hCNTF-secreting cells. Moreover, QA produced a marked hyperactivity, an inability to use the forelimbs to retrieve food pellets in a staircase test, increased the latency of the rats to remove adhesive stimuli from their paws, and decreased the number of steps taken in a bracing test that assessed motor rigidity. Finally, the QA-infused animals were impaired in tests of cognitive function — the Morris water maze spatial learning task, and the delayed nonmatching-to-position operant test of working memory. Prior implantation with hCNTF-secreting cells prevented the onset of all the above deficits such that implanted animals were nondistinguishable from sham-lesioned controls. At the conclusion of behavioral testing, 19 days following QA, the animals were sacrificed for neurochemical determination of striatal choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) levels. This analysis revealed that QA decreased striatal ChAT levels by 35% and striatal GAD levels by 45%. In contrast, hCNTF-treated animals did not exhibit any decrease in ChAT levels and only a 10% decrease in GAD levels. These results support the concepts that implants of polymer-encapsulated hCNTF-releasing cells can be used to protect striatal neurons from excitotoxic damage, produce extensive behavioral protection as a result of that neuronal sparing, and that this strategy may ultimately prove relevant for the treatment of HD." @default.
• W4236028560 created "2022-05-12" @default.
• W4236028560 creator A5021929537 @default.
• W4236028560 creator A5034381813 @default.
• W4236028560 creator A5058329121 @default.
• W4236028560 creator A5063135132 @default.
• W4236028560 creator A5071080598 @default.
• W4236028560 creator A5071945516 @default.
• W4236028560 creator A5086944072 @default.
• W4236028560 date "1997-05-01" @default.
• W4236028560 modified "2023-10-15" @default.
• W4236028560 title "Cellular Delivery of Human Cntf Prevents Motor and Cognitive Dysfunction in a Rodent Model of Huntington's Disease" @default.
• W4236028560 cites W1500403088 @default.
• W4236028560 cites W1517125774 @default.
• W4236028560 cites W1590012920 @default.
• W4236028560 cites W1598732229 @default.
• W4236028560 cites W1652129229 @default.
• W4236028560 cites W1805673099 @default.
• W4236028560 cites W1840016921 @default.
• W4236028560 cites W1853026346 @default.
• W4236028560 cites W1910864442 @default.
• W4236028560 cites W1963860879 @default.
• W4236028560 cites W1965055778 @default.
• W4236028560 cites W1968810631 @default.
• W4236028560 cites W1972028705 @default.
• W4236028560 cites W1972490273 @default.
• W4236028560 cites W1972531020 @default.
• W4236028560 cites W1973061682 @default.
• W4236028560 cites W1980766639 @default.
• W4236028560 cites W1983557415 @default.
• W4236028560 cites W1983978018 @default.
• W4236028560 cites W1985933922 @default.
• W4236028560 cites W1991335740 @default.
• W4236028560 cites W1991870151 @default.
• W4236028560 cites W1992226987 @default.
• W4236028560 cites W1993068285 @default.
• W4236028560 cites W1993634331 @default.
• W4236028560 cites W1993709327 @default.
• W4236028560 cites W1995130178 @default.
• W4236028560 cites W2002763309 @default.
• W4236028560 cites W2003898160 @default.
• W4236028560 cites W2004601258 @default.
• W4236028560 cites W2008508692 @default.
• W4236028560 cites W2009063082 @default.
• W4236028560 cites W2009173102 @default.
• W4236028560 cites W2011406750 @default.
• W4236028560 cites W2012271737 @default.
• W4236028560 cites W2012872347 @default.
• W4236028560 cites W2013831553 @default.
• W4236028560 cites W2015041369 @default.
• W4236028560 cites W2015538775 @default.
• W4236028560 cites W2016575029 @default.
• W4236028560 cites W2017217471 @default.
• W4236028560 cites W2018177128 @default.
• W4236028560 cites W2019874433 @default.
• W4236028560 cites W2025254813 @default.
• W4236028560 cites W2026371537 @default.
• W4236028560 cites W2029956630 @default.
• W4236028560 cites W2031283967 @default.
• W4236028560 cites W2031423487 @default.
• W4236028560 cites W2033027472 @default.
• W4236028560 cites W2036297334 @default.
• W4236028560 cites W2037256941 @default.
• W4236028560 cites W2039776384 @default.
• W4236028560 cites W2043719154 @default.
• W4236028560 cites W2045584836 @default.
• W4236028560 cites W2046582345 @default.
• W4236028560 cites W2046739492 @default.
• W4236028560 cites W2046963526 @default.
• W4236028560 cites W2047482441 @default.
• W4236028560 cites W2047945439 @default.
• W4236028560 cites W2050304234 @default.
• W4236028560 cites W2054007800 @default.
• W4236028560 cites W2054021444 @default.
• W4236028560 cites W2057835832 @default.
• W4236028560 cites W2058176457 @default.
• W4236028560 cites W2060646430 @default.
• W4236028560 cites W2062016306 @default.
• W4236028560 cites W2063664890 @default.
• W4236028560 cites W2064244593 @default.
• W4236028560 cites W2065723600 @default.
• W4236028560 cites W2068230856 @default.
• W4236028560 cites W2068568687 @default.
• W4236028560 cites W2068609935 @default.
• W4236028560 cites W2070159820 @default.
• W4236028560 cites W2073687274 @default.
• W4236028560 cites W2074872796 @default.
• W4236028560 cites W2082995803 @default.
• W4236028560 cites W2084287845 @default.
• W4236028560 cites W2089136890 @default.
• W4236028560 cites W2093047883 @default.
• W4236028560 cites W2123928283 @default.
• W4236028560 cites W2136049998 @default.
• W4236028560 cites W2144077220 @default.
• W4236028560 cites W2145213346 @default.
• W4236028560 cites W2159557945 @default.
• W4236028560 cites W2164587556 @default.
• W4236028560 cites W2181272616 @default.

• next