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- W4236029397 abstract "The human genome is the blueprint of the human body. It encodes valuable yet implicit clues about our physical and mental health. Human health and diseases are affected by inherited genes and environmental factors. A typical example is cancer, thought to be a genetic disease, where a collection of somatic mutations drives the progression of the disease. Tracking the disease roots down to the DNA alphabet promises a clearer understanding of disease mechanisms. DNA alphabets may also serve as stable biomarkers, suggesting personalized estimates of disease risks or drug response rates. In this chapter, we explore techniques critical for the success of genomic data analysis. Special emphasis is placed on the adaptive exploration of associations between clinical phenotypes and genomic variants. Furthermore, we address the skillful analysis of complex somatic structural variations in the cancer genome. An effective use of these skills will lead toward a deeper understanding and even new treatment strategies of various diseases, as is evidenced by the case studies." @default.
- W4236029397 created "2022-05-12" @default.
- W4236029397 creator A5034268786 @default.
- W4236029397 date "2013-01-01" @default.
- W4236029397 modified "2023-10-06" @default.
- W4236029397 title "Genomics" @default.
- W4236029397 doi "https://doi.org/10.1533/9781908818232.9" @default.
- W4236029397 hasPublicationYear "2013" @default.
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