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- W4236030341 abstract "This chapter provides an overview of adverse effects of antipyretic analgesics. In a case of salicylate poisoning, a combination of peritoneal dialysis with fluid containing albumin, alkaline diuresis and hemodialysis was used in the treatment with a “salicylate level” of 960 μg/ml. The adverse effects of aspirin on platelet function and hemostasis are now well-known. Unexpected excessive blood loss during surgery in children has been attributed to aspirin-induced platelet dysfunction and in three children undergoing elective plastic surgery, blood losses of 20, 25, and 95% of the blood volume instead of anticipated losses of 5, 5, and 30% were attributed to the previous use of aspirin. Salicylates may occasionally cause bleeding through hypoprothrombinemia when given in high dosage. Predisposing conditions include liver disease, gastrectomy, malnutrition, and malabsorption. Analgesic nephropathy is the expression of an unrecognized pattern of disease resulting from the unique structure and function of the renal medulla. Injury first occurs in the renal papilla, and progressively destroys the inner medulla leading to papillary necrosis, cortical atrophy, and chronic renal failure." @default.
- W4236030341 created "2022-05-12" @default.
- W4236030341 creator A5018621292 @default.
- W4236030341 date "1979-01-01" @default.
- W4236030341 modified "2023-10-17" @default.
- W4236030341 title "Antipyretic analgesics" @default.
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- W4236030341 doi "https://doi.org/10.1016/s0378-6080(79)80012-4" @default.
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