FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236031306> ?p ?o ?g. }

• W4236031306 endingPage "2854" @default.
• W4236031306 startingPage "2854" @default.
• W4236031306 abstract "Abstract Background: Pancreatic cancer is one of the most malignant tumors. The prognosis of patients with pancreatic cancer remains poor, with a 5-year survival rate of less than 10%. Therefore, identification of new biomarkers and development of therapeutic drugs are urgent issues. As a result of genetic research using public database, we focused on Cofilin-1. In recent years, it has been revealed that cancer cells form invadopodia to destroy extracellular matrix and cause hematogenous metastasis, and it is suggested that Cofilin-1 has a key role in stabilizing the structure of the invadopodia. However the significance of Cofilin-1 expression in cancer invasion is not clear. The purpose of this study is to verify the relationship between the expression of Cofilin-1 and patient’s prognosis in pancreatic cancer. Methods: At first, we examined the relationship between Cofilin-1 expression level and clinicopathological factors or prognosis using GSE21501 and TCGA, which are public databases of patients with pancreatic cancer. We set the cut-off value, and divided into the two groups, the high Cofilin-1 and low groups. Then, we evaluated expression of Cofilin-1 with immunohistochemical (IHC) staining in 200 pancreatic cancer patients who underwent curative surgery during April 2004 to March 2018 at the department of gastroenterological surgery, Kumamoto University. After that, we examined the relationship between Cofilin-1 expression and prognosis. Results: In silico analyses using GSE21501 and TCGA dataset, high expression of Cofilin-1 is associated with early recurrence and poor prognosis. Then, we evaluated expression of Cofilin-1 with IHC staining using original scoring. The score is calculated by multiplying each scores classified into 4 stages from 0 to 3 in intensity of Cofilin-1 expression and area of that. 0 to 3 of the score was the low expression group (n=93), 4 to 9 is the high expression group (n=107). The result showed that high Cofilin-1 expression is associated with high occurrence of lymph node metastasis. In addition, both the relapse free and overall survivals were significantly worse in the high Cofilin-1 group. Cox proportional hazard analysis revealed that the high Cofilin-1 expression was an independent poor prognostic predictor. Conclusion: In both silico analysis and IHC staining, high Cofilin-1 expression is associated with poor prognosis, especially high recurrence rate in patients with pancreatic cancer. Cofilin-1 may be useful as a biomarker for early recurrence in pancreatic cancer. Citation Format: Rumi Itoyama, Shigeki Nakagawa, Toshihiko Yusa, Yosuke Nakao, Takanobu Yamao, Naoki Umezaki, Tatsunori Miyata, Hirohisa Okabe, Hiromitsu Hayashi, Katsunori Imai, Yo-ichi Yamashita, Akira Chikamoto, Hideo Baba. Clinical significance of Cofilin-1 expression in pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2854." @default.
• W4236031306 created "2022-05-12" @default.
• W4236031306 creator A5012084024 @default.
• W4236031306 creator A5017859885 @default.
• W4236031306 creator A5025877176 @default.
• W4236031306 creator A5039564679 @default.
• W4236031306 creator A5041773111 @default.
• W4236031306 creator A5049117363 @default.
• W4236031306 creator A5049992114 @default.
• W4236031306 creator A5058936946 @default.
• W4236031306 creator A5085789327 @default.
• W4236031306 creator A5086141994 @default.
• W4236031306 creator A5089439603 @default.
• W4236031306 creator A5090591767 @default.
• W4236031306 creator A5090839601 @default.
• W4236031306 date "2019-07-01" @default.
• W4236031306 modified "2023-09-27" @default.
• W4236031306 title "Abstract 2854: Clinical significance of Cofilin-1 expression in pancreatic cancer" @default.
• W4236031306 doi "https://doi.org/10.1158/1538-7445.am2019-2854" @default.
• W4236031306 hasPublicationYear "2019" @default.
• W4236031306 type Work @default.
• W4236031306 citedByCount "0" @default.
• W4236031306 crossrefType "journal-article" @default.
• W4236031306 hasAuthorship W4236031306A5012084024 @default.
• W4236031306 hasAuthorship W4236031306A5017859885 @default.
• W4236031306 hasAuthorship W4236031306A5025877176 @default.
• W4236031306 hasAuthorship W4236031306A5039564679 @default.
• W4236031306 hasAuthorship W4236031306A5041773111 @default.
• W4236031306 hasAuthorship W4236031306A5049117363 @default.
• W4236031306 hasAuthorship W4236031306A5049992114 @default.
• W4236031306 hasAuthorship W4236031306A5058936946 @default.
• W4236031306 hasAuthorship W4236031306A5085789327 @default.
• W4236031306 hasAuthorship W4236031306A5086141994 @default.
• W4236031306 hasAuthorship W4236031306A5089439603 @default.
• W4236031306 hasAuthorship W4236031306A5090591767 @default.
• W4236031306 hasAuthorship W4236031306A5090839601 @default.
• W4236031306 hasBestOaLocation W42360313061 @default.
• W4236031306 hasConcept C121608353 @default.
• W4236031306 hasConcept C126322002 @default.
• W4236031306 hasConcept C142669718 @default.
• W4236031306 hasConcept C142724271 @default.
• W4236031306 hasConcept C143998085 @default.
• W4236031306 hasConcept C1491633281 @default.
• W4236031306 hasConcept C204232928 @default.
• W4236031306 hasConcept C2776601116 @default.
• W4236031306 hasConcept C2779013556 @default.
• W4236031306 hasConcept C2780210213 @default.
• W4236031306 hasConcept C2993400109 @default.
• W4236031306 hasConcept C502942594 @default.
• W4236031306 hasConcept C54355233 @default.
• W4236031306 hasConcept C71924100 @default.
• W4236031306 hasConcept C86803240 @default.
• W4236031306 hasConceptScore W4236031306C121608353 @default.
• W4236031306 hasConceptScore W4236031306C126322002 @default.
• W4236031306 hasConceptScore W4236031306C142669718 @default.
• W4236031306 hasConceptScore W4236031306C142724271 @default.
• W4236031306 hasConceptScore W4236031306C143998085 @default.
• W4236031306 hasConceptScore W4236031306C1491633281 @default.
• W4236031306 hasConceptScore W4236031306C204232928 @default.
• W4236031306 hasConceptScore W4236031306C2776601116 @default.
• W4236031306 hasConceptScore W4236031306C2779013556 @default.
• W4236031306 hasConceptScore W4236031306C2780210213 @default.
• W4236031306 hasConceptScore W4236031306C2993400109 @default.
• W4236031306 hasConceptScore W4236031306C502942594 @default.
• W4236031306 hasConceptScore W4236031306C54355233 @default.
• W4236031306 hasConceptScore W4236031306C71924100 @default.
• W4236031306 hasConceptScore W4236031306C86803240 @default.
• W4236031306 hasIssue "13_Supplement" @default.
• W4236031306 hasLocation W42360313061 @default.
• W4236031306 hasOpenAccess W4236031306 @default.
• W4236031306 hasPrimaryLocation W42360313061 @default.
• W4236031306 hasRelatedWork W1499339123 @default.
• W4236031306 hasRelatedWork W2043890160 @default.
• W4236031306 hasRelatedWork W2337680646 @default.
• W4236031306 hasRelatedWork W2346074809 @default.
• W4236031306 hasRelatedWork W2353600181 @default.
• W4236031306 hasRelatedWork W2582912872 @default.
• W4236031306 hasRelatedWork W2728479436 @default.
• W4236031306 hasRelatedWork W3173207637 @default.
• W4236031306 hasRelatedWork W4306156633 @default.
• W4236031306 hasRelatedWork W4311290603 @default.
• W4236031306 hasVolume "79" @default.
• W4236031306 isParatext "false" @default.
• W4236031306 isRetracted "false" @default.
• W4236031306 workType "article" @default.