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- W4236035733 abstract "Human leukocyte antigen B (HLA-B) is responsible for presenting peptides to immune cells and plays a critical role in normal immune recognition of pathogens. A variant allele, HLA-B*57:01, is associated with increased risk of a hypersensitivity reaction to the anti-HIV drug abacavir. In the absence of genetic prescreening, hypersensitivity affects ~6% of patients and can be life-threatening with repeated dosing. We provide recommendations (updated periodically at http://www.pharmkgb.org) for the use of abacavir based on HLA-B genotype. Clinical Pharmacology & Therapeutics (2012); 91 4, 734–738. doi:10.1038/clpt.2011.355" @default.
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- W4236035733 date "2012-02-29" @default.
- W4236035733 modified "2023-10-17" @default.
- W4236035733 title "Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing" @default.
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- W4236035733 doi "https://doi.org/10.1038/clpt.2011.355" @default.
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