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• W4236036050 abstract "Event Abstract Back to Event CD8+ T cells stimulated with autologous epitopes derived from protease and reverse transcriptase of HIV-1 Colombian strain subtype B exhibit a polyfunctional profile compared with consensus epitopes. Liliana A. Acevedo-Saenz1, Daniela Vanegas-Otálvaro1, Francisco J. Diaz1 and Paula A. Velilla-Hernández1* 1 Universidad de Antioquia, Facultad de Medicina, Colombia Several studies are focused in the description of genetics variants and immune response that contributes to the control of viral load and disease outcome during human immunodeficiency virus (HIV) infection. Genetic studies have reported that the human leukocyte antigen (HLA) class I alleles are a major determinant in the progression of the disease, indicating that the effect of certain HLA alleles on HIV-specific CD8+ T cell responses play a major role in controlling the virus replication. However, the HIV proteins are subject to high rates of mutation as a result of high viral replication and the error prone HIV reverse transcriptase, which lead to high antigenic variability of the virus. This sequence variability has an important influence in the cellular immune response, where a single amino acid change (mutation) within a CD8+ T cell epitope could impact the recognition of these epitopes and the induction of a functional prolife. HIV evades the cellular immune response by the selection of HLA-restricted CD8+ T cell escape mutations that allows the virus to evade the immune recognition, and these mutations can be selected in acute and/or chronic phase of the infection. These escape mutations could accumulate in the population, suggesting the loss of target epitopes. Also, a higher breadth and magnitude of CD8+ T cell response against autologous peptides compared to clade-B consensus peptides has been described, indicating a functional importance of HIV sequence variation in the induction of antiviral profile. In this study, we first explored the frequency of expression of HLA class I alleles in 74 chronically HIV-1 infected Colombian individuals. We selected the individuals that expressed the HLA-B*35, -B*44 and –B*51 alleles, considering the high frequency of these alleles in the Colombian population. Then, we identified several autologous epitopes restricted to these HLA alleles; the consensus and autologous epitopes whose frequency was greater than 5% were selected in the 614 HIV-1 Colombian sequences evaluated. Finally, the functional profile of CD8+ T cells stimulated with these autologous and consensus HIV-1 epitopes was determined. Overall, for the three HLA alleles studied we identified three consensus epitopes for each allele, and a total of 19 variants. There was a predominance of monofunctional response for all the evaluated epitopes, which could be associated with the state of chronic infection of our patients. However, for HLA-B*44 and –B*51, most of autologous epitopes induced a greater polyfunctional profile compared with the consensus epitopes. In contrast, for HLA-B*35 the greater polyfunctional profile was observed in consensus epitopes, at the expense of IL-2+ Perforin+, IL-2+ TNF+ and Perforin+ MIP1+ subsets. For the epitopes restricted to HLA-B*44, the IL-2+ MIP1+, IL-2+ Perforin+, Perforin+ MIP1+, IFN+ Perforin+ TNF+ and IL-2+ IFN+ Perforin+ TNF+ responses predominated in response to autologous epitopes. However, in the case of IEICGHTAIG variant, there is a decrease in the polyfunctional profile. Regarding the epitopes restricted to HLA-B*51, the highest responses were MIP1+ Perforin+, IFN+ MIP1+, IFN+ Perforin+ TNF+, IFN+ MIP1+ Perforin+, IFN+ IL-2+ MIP1+ TNF+ and IFN+ MIP1+ Perforin+ TNF+ subsets. These preliminary results suggest that most autologous epitopes induce a polyfunctional response; however, some mutations within these epitopes seem to affect the polyfunctional response of CD8+ T cells. Acknowledgements CODI – Convocatoria programática 2013-2014, área de ciencias biomédicas y de salud. Código 2562. Keywords: CD8+ T cells, HIV-1, Functional profile, Peptides, Colombia Conference: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología, Medellin, Colombia, 13 Oct - 16 Oct, 2015. Presentation Type: Poster Presentation Topic: Infectious and parasitic diseases Citation: Acevedo-Saenz LA, Vanegas-Otálvaro D, Diaz FJ and Velilla-Hernández PA (2015). CD8+ T cells stimulated with autologous epitopes derived from protease and reverse transcriptase of HIV-1 Colombian strain subtype B exhibit a polyfunctional profile compared with consensus epitopes.. Front. Immunol. Conference Abstract: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología. doi: 10.3389/conf.fimmu.2015.05.00168 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 31 May 2015; Published Online: 14 Sep 2015. * Correspondence: Dr. Paula A Velilla-Hernández, Universidad de Antioquia, Facultad de Medicina, Medellín, Antioquia, 050010, Colombia, pvelilla@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Liliana A Acevedo-Saenz Daniela Vanegas-Otálvaro Francisco J Diaz Paula A Velilla-Hernández Google Liliana A Acevedo-Saenz Daniela Vanegas-Otálvaro Francisco J Diaz Paula A Velilla-Hernández Google Scholar Liliana A Acevedo-Saenz Daniela Vanegas-Otálvaro Francisco J Diaz Paula A Velilla-Hernández PubMed Liliana A Acevedo-Saenz Daniela Vanegas-Otálvaro Francisco J Diaz Paula A Velilla-Hernández Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W4236036050 title "CD8+ T cells stimulated with autologous epitopes derived from protease and reverse transcriptase of HIV-1 Colombian strain subtype B exhibit a polyfunctional profile compared with consensus epitopes." @default.
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