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- W4236038579 abstract "This chapter presents animal models of global and focal cerebral ischemia. Widely employed models of global ischemia in rodents include: a “four-vessel occlusion” model in rats, in which both vertebral arteries are permanently electrocoagulated in a first-stage operation; and a “two-vessel occlusion” model in which the two carotid arteries are transiently occluded and the mean arterial blood pressure is simultaneously reduced to 45–50 mmHg by arterial exsanguination. Each of these models gives rise to transient high-grade ischemia of forebrain structures: local CBF is typically reduced to 0–3% of control in neocortex, hippocampus, and basal ganglia and is slightly higher in thalamus. In the best hands, these models yield rather consistent neuropathologic outcome as judged by quantitative neuronal counting, but this consistency depends upon scrupulous attention to control of physiologic variables in the intra- and peri-insult periodsmincluding arterial blood pressure, blood gases and pH, core temperature, cranial temperature, and plasma glucose level. Animal models of focal ischemia are generally intended to replicate features of human focal ischemic stroke produced by occlusion of a single cerebral artery. Thus, the vast majority of animal models of focal ischemia employ middle cerebral artery (MCA) occlusion." @default.
- W4236038579 created "2022-05-12" @default.
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- W4236038579 date "1997-01-01" @default.
- W4236038579 modified "2023-09-27" @default.
- W4236038579 title "Animal Models of Global and Focal Cerebral Ischemia" @default.
- W4236038579 doi "https://doi.org/10.1016/b978-012743170-3/50035-2" @default.
- W4236038579 hasPublicationYear "1997" @default.
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