FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236039728> ?p ?o ?g. }

• W4236039728 endingPage "S552" @default.
• W4236039728 startingPage "S552" @default.
• W4236039728 abstract "The benefit of palliative radiation (RT) for painful bone metastases is usually assessed by improvement in pain; analgesic intake may confound the assessment of the true impact of RT. In patients (pts) with multiple bone metastases, increasing pain level and analgesic use after RT may reflect progression of other metastases rather than lack of response in the site treated, and may obscure the true benefits of RT. This study aims to assess which outcomes more closely reflect clinical benefit in pts treated with palliative RT for painful bone metastases. Pts with painful bone metastases seen in the Palliative Radiation Oncology Program at Princess Margaret Hospital, who consented to the study, completed a baseline questionnaire documenting sites of pain, pain score, analgesia intake, quality of life (QOL) using linear analogue scale, ECOG performance status (PS), as well as functional tasks affected by pain and scored their ability to perform them, on a 0–10 scale. Patients were telephoned at weeks 1, 2, 4, 6 and 8 after RT and were asked to rate the same measures. Integrated pain score, taking into pt rating of pain and intake of analgesics, was considered improved if analgesic intake was less and pain was improved or stable, or analgesic intake was same and pain was improved. Seventy-six pts were accrued to the study. Pts typically had breast (39%) and lung (25%) primaries, average PS of 1.6, one site requiring radiation (82%), mostly pelvis (43%) or spine (29%); 69% were treated with 20Gy /5 fractions. 74/76 pts identified one (31%) or more (69%) tasks affected by pain; most frequent tasks mentioned were walking (44%) and general self-care/ADLs (32%). 82% stated that pain prevented them from turning in bed. 53 pts (70%) provided sufficient follow-up data to be included in the analysis of response. Pain scores improved early post RT (52% at week (w) 1, 67% at w 2, 75% at w 4), but 33%, 38% and 43% of pts were taking more analgesics at w 1,2 and 4, respectively. Integrated pain scores revealed improvements in 44% pts in w 1 and 55% in w 2; this percentage remained stable throughout w 8. Ability to perform a specific task improved more slowly (36%, 49%, 64% in w 1, 2 and 4 respectively) but showed continuous improvement to 79% by week 8. Turning in bed improved gradually (36% w 1, 49% w 2) but deteriorated by w 6–8. QOL also improved gradually and more modestly (26%, 31% and 39% in w 1, 2 and 4 respectively). The least amount of improvement was seen in PS scores, which improved in only 25% of pts by w 4. Pt reports of various outcomes after palliative RT for painful bone metastases confirm that pain can improve very early post RT, but many pts are on higher doses of analgesics, which need to be considered in attributing the clinical improvement to RT or other measures. Specific functional tasks affected by pain are easily identified and reported by pts, and improve more slowly, but appear to provide a complementary measure of palliative response, that may be less prone to effect of confounding variables, such as analgesics and other sites of pain, and may provide meaningful information to inform patients" @default.
• W4236039728 created "2022-05-12" @default.
• W4236039728 creator A5001413233 @default.
• W4236039728 creator A5002124817 @default.
• W4236039728 creator A5002961136 @default.
• W4236039728 creator A5004496721 @default.
• W4236039728 creator A5032075563 @default.
• W4236039728 creator A5036963802 @default.
• W4236039728 creator A5040285878 @default.
• W4236039728 creator A5054720614 @default.
• W4236039728 creator A5062816009 @default.
• W4236039728 date "2004-09-01" @default.
• W4236039728 modified "2023-09-27" @default.
• W4236039728 title "Radiation for painful bone metastases: Comparison of different measures of palliative response" @default.
• W4236039728 doi "https://doi.org/10.1016/s0360-3016(04)01830-9" @default.
• W4236039728 hasPublicationYear "2004" @default.
• W4236039728 type Work @default.
• W4236039728 citedByCount "0" @default.
• W4236039728 crossrefType "journal-article" @default.
• W4236039728 hasAuthorship W4236039728A5001413233 @default.
• W4236039728 hasAuthorship W4236039728A5002124817 @default.
• W4236039728 hasAuthorship W4236039728A5002961136 @default.
• W4236039728 hasAuthorship W4236039728A5004496721 @default.
• W4236039728 hasAuthorship W4236039728A5032075563 @default.
• W4236039728 hasAuthorship W4236039728A5036963802 @default.
• W4236039728 hasAuthorship W4236039728A5040285878 @default.
• W4236039728 hasAuthorship W4236039728A5054720614 @default.
• W4236039728 hasAuthorship W4236039728A5062816009 @default.
• W4236039728 hasConcept C121608353 @default.
• W4236039728 hasConcept C126322002 @default.
• W4236039728 hasConcept C141071460 @default.
• W4236039728 hasConcept C159110408 @default.
• W4236039728 hasConcept C1862650 @default.
• W4236039728 hasConcept C2776139714 @default.
• W4236039728 hasConcept C2776907518 @default.
• W4236039728 hasConcept C2778357063 @default.
• W4236039728 hasConcept C2779951463 @default.
• W4236039728 hasConcept C2780052408 @default.
• W4236039728 hasConcept C2780820201 @default.
• W4236039728 hasConcept C2781118164 @default.
• W4236039728 hasConcept C2994186709 @default.
• W4236039728 hasConcept C42219234 @default.
• W4236039728 hasConcept C71924100 @default.
• W4236039728 hasConceptScore W4236039728C121608353 @default.
• W4236039728 hasConceptScore W4236039728C126322002 @default.
• W4236039728 hasConceptScore W4236039728C141071460 @default.
• W4236039728 hasConceptScore W4236039728C159110408 @default.
• W4236039728 hasConceptScore W4236039728C1862650 @default.
• W4236039728 hasConceptScore W4236039728C2776139714 @default.
• W4236039728 hasConceptScore W4236039728C2776907518 @default.
• W4236039728 hasConceptScore W4236039728C2778357063 @default.
• W4236039728 hasConceptScore W4236039728C2779951463 @default.
• W4236039728 hasConceptScore W4236039728C2780052408 @default.
• W4236039728 hasConceptScore W4236039728C2780820201 @default.
• W4236039728 hasConceptScore W4236039728C2781118164 @default.
• W4236039728 hasConceptScore W4236039728C2994186709 @default.
• W4236039728 hasConceptScore W4236039728C42219234 @default.
• W4236039728 hasConceptScore W4236039728C71924100 @default.
• W4236039728 hasLocation W42360397281 @default.
• W4236039728 hasOpenAccess W4236039728 @default.
• W4236039728 hasPrimaryLocation W42360397281 @default.
• W4236039728 hasRelatedWork W1805109906 @default.
• W4236039728 hasRelatedWork W2023338216 @default.
• W4236039728 hasRelatedWork W2114557627 @default.
• W4236039728 hasRelatedWork W2164677243 @default.
• W4236039728 hasRelatedWork W2489701077 @default.
• W4236039728 hasRelatedWork W2772216102 @default.
• W4236039728 hasRelatedWork W4220807067 @default.
• W4236039728 hasRelatedWork W4220892544 @default.
• W4236039728 hasRelatedWork W4224300215 @default.
• W4236039728 hasRelatedWork W2396213879 @default.
• W4236039728 hasVolume "60" @default.
• W4236039728 isParatext "false" @default.
• W4236039728 isRetracted "false" @default.
• W4236039728 workType "article" @default.