Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236054676> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4236054676 endingPage "326" @default.
- W4236054676 startingPage "320" @default.
- W4236054676 abstract "Bone marrow stromal cells are a mixed population that contribute to the formation of the hematopoietic microenvironment. The osteogenic lineage includes populations of cells that, in culture, form discrete nodules of mineralized tissue when grown in the presence of ascorbic acid and sodium beta-glycerophosphate. We have used nodule formation to assay for the self-renewal capacity of osteoprogenitor cells in chick bone marrow cultures. To examine the regulatory influence of dexamethasone (Dx), first subcultures were grown continuously or split 1:1 at repeated subculture. Cells in continuous culture exhibited less than two population doublings, while cellular proliferation and alkaline phosphatase area were inhibited by 10(-8) mol/L Dx. Cells in split (redistributed) cultures exhibited up to 14 population doublings and cellular proliferation was also inhibited by Dx. In contrast with continuous cultures, redistributed cultures treated with Dx had increased alkaline phosphatase area and 15-fold larger amounts of mineralized tissue formation than controls. Osteogenesis was sustained for up to four subcultures and the ratio of mineralized tissue area to alkaline phosphotase positive cell area was at most 0.55. These data indicate that the osteogenic lineage of bone marrow stromal cells contains self-renewing progenitors that are recruited by Dx in culture and that at a maximum, only 55% of the alkaline phosphatase-positive cell population contributes to osteogenesis." @default.
- W4236054676 created "2022-05-12" @default.
- W4236054676 creator A5049460440 @default.
- W4236054676 creator A5057035481 @default.
- W4236054676 creator A5084545859 @default.
- W4236054676 creator A5087945478 @default.
- W4236054676 date "1992-01-15" @default.
- W4236054676 modified "2023-09-27" @default.
- W4236054676 title "Dexamethasone recruitment of self-renewing osteoprogenitor cells in chick bone marrow stromal cell cultures" @default.
- W4236054676 doi "https://doi.org/10.1182/blood.v79.2.320.bloodjournal792320" @default.
- W4236054676 hasPublicationYear "1992" @default.
- W4236054676 type Work @default.
- W4236054676 citedByCount "0" @default.
- W4236054676 crossrefType "journal-article" @default.
- W4236054676 hasAuthorship W4236054676A5049460440 @default.
- W4236054676 hasAuthorship W4236054676A5057035481 @default.
- W4236054676 hasAuthorship W4236054676A5084545859 @default.
- W4236054676 hasAuthorship W4236054676A5087945478 @default.
- W4236054676 hasBestOaLocation W42360546761 @default.
- W4236054676 hasConcept C109159458 @default.
- W4236054676 hasConcept C153911025 @default.
- W4236054676 hasConcept C160160445 @default.
- W4236054676 hasConcept C16930146 @default.
- W4236054676 hasConcept C181199279 @default.
- W4236054676 hasConcept C201750760 @default.
- W4236054676 hasConcept C203014093 @default.
- W4236054676 hasConcept C2780007613 @default.
- W4236054676 hasConcept C28328180 @default.
- W4236054676 hasConcept C2908647359 @default.
- W4236054676 hasConcept C502942594 @default.
- W4236054676 hasConcept C54355233 @default.
- W4236054676 hasConcept C55493867 @default.
- W4236054676 hasConcept C71924100 @default.
- W4236054676 hasConcept C81885089 @default.
- W4236054676 hasConcept C86803240 @default.
- W4236054676 hasConcept C87863119 @default.
- W4236054676 hasConcept C89423630 @default.
- W4236054676 hasConcept C95444343 @default.
- W4236054676 hasConcept C99454951 @default.
- W4236054676 hasConceptScore W4236054676C109159458 @default.
- W4236054676 hasConceptScore W4236054676C153911025 @default.
- W4236054676 hasConceptScore W4236054676C160160445 @default.
- W4236054676 hasConceptScore W4236054676C16930146 @default.
- W4236054676 hasConceptScore W4236054676C181199279 @default.
- W4236054676 hasConceptScore W4236054676C201750760 @default.
- W4236054676 hasConceptScore W4236054676C203014093 @default.
- W4236054676 hasConceptScore W4236054676C2780007613 @default.
- W4236054676 hasConceptScore W4236054676C28328180 @default.
- W4236054676 hasConceptScore W4236054676C2908647359 @default.
- W4236054676 hasConceptScore W4236054676C502942594 @default.
- W4236054676 hasConceptScore W4236054676C54355233 @default.
- W4236054676 hasConceptScore W4236054676C55493867 @default.
- W4236054676 hasConceptScore W4236054676C71924100 @default.
- W4236054676 hasConceptScore W4236054676C81885089 @default.
- W4236054676 hasConceptScore W4236054676C86803240 @default.
- W4236054676 hasConceptScore W4236054676C87863119 @default.
- W4236054676 hasConceptScore W4236054676C89423630 @default.
- W4236054676 hasConceptScore W4236054676C95444343 @default.
- W4236054676 hasConceptScore W4236054676C99454951 @default.
- W4236054676 hasIssue "2" @default.
- W4236054676 hasLocation W42360546761 @default.
- W4236054676 hasOpenAccess W4236054676 @default.
- W4236054676 hasPrimaryLocation W42360546761 @default.
- W4236054676 hasRelatedWork W23158175 @default.
- W4236054676 hasRelatedWork W26440626 @default.
- W4236054676 hasRelatedWork W30453952 @default.
- W4236054676 hasRelatedWork W551869 @default.
- W4236054676 hasRelatedWork W6178399 @default.
- W4236054676 hasRelatedWork W6386332 @default.
- W4236054676 hasRelatedWork W789684 @default.
- W4236054676 hasRelatedWork W8143991 @default.
- W4236054676 hasRelatedWork W8374405 @default.
- W4236054676 hasRelatedWork W8506351 @default.
- W4236054676 hasVolume "79" @default.
- W4236054676 isParatext "false" @default.
- W4236054676 isRetracted "false" @default.
- W4236054676 workType "article" @default.