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• W4236056325 abstract "You have accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Riehl Brandon D., Lee Jeong Soon, Ha Ligyeom and Lim Jung Yul 2015Fluid-flow-induced mesenchymal stem cell migration: role of focal adhesion kinase and RhoA kinase sensorsJ. R. Soc. Interface.122015030020150300http://doi.org/10.1098/rsif.2015.0300SectionYou have accessCorrectionsFluid-flow-induced mesenchymal stem cell migration: role of focal adhesion kinase and RhoA kinase sensors Brandon D. Riehl Brandon D. Riehl Google Scholar Find this author on PubMed Search for more papers by this author , Jeong Soon Lee Jeong Soon Lee Google Scholar Find this author on PubMed Search for more papers by this author , Ligyeom Ha Ligyeom Ha Google Scholar Find this author on PubMed Search for more papers by this author and Jung Yul Lim Jung Yul Lim Google Scholar Find this author on PubMed Search for more papers by this author Brandon D. Riehl Brandon D. Riehl Google Scholar Find this author on PubMed Search for more papers by this author , Jeong Soon Lee Jeong Soon Lee Google Scholar Find this author on PubMed Search for more papers by this author , Ligyeom Ha Ligyeom Ha Google Scholar Find this author on PubMed Search for more papers by this author and Jung Yul Lim Jung Yul Lim Google Scholar Find this author on PubMed Search for more papers by this author Published:06 June 2015https://doi.org/10.1098/rsif.2015.0300This article corrects the followingResearch ArticleFluid-flow-induced mesenchymal stem cell migration: role of focal adhesion kinase and RhoA kinase sensorshttps://doi.org/10.1098/rsif.2014.1351 Brandon D. Riehl, Jeong Soon Lee, Ligyeom Ha and Jung Yul Lim volume 12issue 104Journal of The Royal Society Interface06 March 2015J. R. Soc. Interface12, 20141351 (14 January 2015; Published online) (doi:10.1098/rsif.2014.1351)We would like to correct a misprint. In figure 5g of the published article, FF15 is written incorrectly as FF125 in the y-axis. Below is the figure with correct captions. Figure 5. FAK silencing decreases RMS displacement and motility coefficient, whereas ROCK silencing increases them especially under flow conditions. (a) MSCs with ROCK–shRNA had an increased total cell displacement. (b) The confinement ratio showed a similar increase for ROCK–shRNA. (c) No significant changes were detected for the arrest coefficient other than a lower value for ROCK–shRNA than for FAK–shRNA. (d) Silenced cells still showed preferred migration along the flow direction. (e) ROCK-silenced cells under flow spent significantly more time migrating with the flow direction. (f) Silenced cells also showed a peak speed after the flow onset. (g) RMS displacement plotted against square root of time showed shear stress-dependent increases. (h) In the same type of plot, FAK–shRNA decreased RMS displacement for both static and flow conditions. ROCK interference increased RMS displacement especially under flow conditions. (i) Calculated motility coefficient increased with increasing shear stress. It had lower values for FAK–shRNA for both static and shear conditions relative to vector control counterparts. MSCs with ROCK–shRNA at FF15 exhibited the greatest motility coefficient among test conditions. The bar graphs are presented as the mean with SEM. Static control, plus; FF2, square; FF15, circle; FF25, inverted triangle; FAK–shRNA static, diamond; FAK–shRNA FF15, multiplication symbol; ROCK–shRNA static, left inverted triangle; ROCK–shRNA FF15, delta symbol. *, ** and ***: p < 0.05, 0.01, and 0.001 compared with vector control static. ‡, ‡‡ and ‡‡‡: p < 0.05, 0.01 and 0.001 compared with FAK–shRNA static. ++ and +++: p < 0.01 and 0.001 compared with ROCK–shRNA static.Download figureOpen in new tabDownload PowerPoint Previous Article VIEW FULL TEXT DOWNLOAD PDF FiguresRelatedReferencesDetailsCited by Sun Y, Yuan Y, Wu W, Lei L and Zhang L (2021) The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation, Cell & Bioscience, 10.1186/s13578-021-00601-9, 11:1, Online publication date: 1-Dec-2021. Corrigan M, Johnson G, Stavenschi E, Riffault M, Labour M and Hoey D (2018) TRPV4-mediates oscillatory fluid shear mechanotransduction in mesenchymal stem cells in part via the primary cilium, Scientific Reports, 10.1038/s41598-018-22174-3, 8:1, Online publication date: 1-Dec-2018. Doolin M and Stroka K (2018) P hysical confinement alters cytoskeletal contributions towards human mesenchymal stem cell migration , Cytoskeleton, 10.1002/cm.21433, 75:3, (103-117), Online publication date: 1-Mar-2018. Riehl B, Lee J, Ha L, Kwon I, Lim J and Genetos D (2017) Flowtaxis of osteoblast migration under fluid shear and the effect of RhoA kinase silencing, PLOS ONE, 10.1371/journal.pone.0171857, 12:2, (e0171857) Related articlesFluid-flow-induced mesenchymal stem cell migration: role of focal adhesion kinase and RhoA kinase sensors06 March 2015Journal of The Royal Society Interface This IssueJune 2015Volume 12Issue 107 Article InformationDOI:https://doi.org/10.1098/rsif.2015.0300PubMed:25926700Published by:Royal SocietyOnline ISSN:1742-5662History: Published online06/06/2015Published in print06/06/2015 License:© 2015 The Author(s) Published by the Royal Society. All rights reserved. Citations and impact Subjectsbioengineering" @default.
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