FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236057011> ?p ?o ?g. }

• W4236057011 abstract "Abstract Background Lung cancer has been the leading cause of tumor related death, and 80%~85% of it is non-small cell lung cancer (NSCLC). Even with the rising molecular targeted therapies, for example EGFR, ROS1 and ALK, the treatment is still challenging. The study is to identify credible responsible genes during the development of NSCLC using bioinformatic analysis, developing new prognostic biomarkers and potential gene targets to the disease. Methods Firstly, three genes expression profiles GSE44077, GSE18842 and GSE33532 were picked from Gene Expression Omnibus (GEO) to analyze the genes with different expression level (GDEs) between NSCLC and normal lung samples, and the cellular location, molecular function and the biology pathways the GDEs enriched in were analyzed. Then, gene function modules of GDEs were explored based on the protein-protein interaction network (PPI), and the top module which contains most genes was identified, followed by containing genes annotation and survival analysis. Moreover, multivariate cox regression analysis was performed in addition to the Kaplan meier survival to narrow down the key genes scale. Further, the clinical pathological features of the picked key genes were explored using TCGA data. Results Three GEO profiles shared a total of 664 GDEs, including 232 up-regulated and 432 down-regulated genes. Based on the GDEs PPI network, the top function module containing a total of 69 genes was identified, and 31 of 69 genes were mitotic cell cycle regulation related. And survival analysis of the 31 genes revealed that 17/31 genes statistical significantly related to NSCLC overall survival, including 4 spindle assembly checkpoints, namely NDC80, BUB1B, MAD2L1 and AURKA. Further, multivariate cox regression analysis identified NDC80 and MAD2L1 as independent prognostic indicators in lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) respectively. Interestingly, pearson correlation analysis indicated strong connection between the four genes NDC80, BUB1B, MAD2L1 and AURKA, and their clinical pathological features were addressed. Conclusions Using bioinformatic analysis of GEO combined with TCGA data, we revealed two independent prognostic indicators in LUAD and LUSC respectively and analyzed their clinical features. However, more detailed experiments and clinical trials are needed to verify their drug targets role in clinical medical use." @default.
• W4236057011 created "2022-05-12" @default.
• W4236057011 creator A5010051114 @default.
• W4236057011 creator A5010645318 @default.
• W4236057011 creator A5021601948 @default.
• W4236057011 creator A5022526821 @default.
• W4236057011 creator A5025783986 @default.
• W4236057011 creator A5030775427 @default.
• W4236057011 creator A5033732336 @default.
• W4236057011 creator A5042316807 @default.
• W4236057011 creator A5048794978 @default.
• W4236057011 creator A5065646419 @default.
• W4236057011 creator A5068602145 @default.
• W4236057011 creator A5082881860 @default.
• W4236057011 creator A5082963441 @default.
• W4236057011 date "2020-07-16" @default.
• W4236057011 modified "2023-10-18" @default.
• W4236057011 title "Bioinformatic Analysis Revealing Mitotic Spindle Assembly regulated NDC80 and MAD2L1 as Prognostic Biomarkers in Non-Small Cell Lung Cancer Development" @default.
• W4236057011 doi "https://doi.org/10.21203/rs.3.rs-43770/v1" @default.
• W4236057011 hasPublicationYear "2020" @default.
• W4236057011 type Work @default.
• W4236057011 citedByCount "0" @default.
• W4236057011 crossrefType "posted-content" @default.
• W4236057011 hasAuthorship W4236057011A5010051114 @default.
• W4236057011 hasAuthorship W4236057011A5010645318 @default.
• W4236057011 hasAuthorship W4236057011A5021601948 @default.
• W4236057011 hasAuthorship W4236057011A5022526821 @default.
• W4236057011 hasAuthorship W4236057011A5025783986 @default.
• W4236057011 hasAuthorship W4236057011A5030775427 @default.
• W4236057011 hasAuthorship W4236057011A5033732336 @default.
• W4236057011 hasAuthorship W4236057011A5042316807 @default.
• W4236057011 hasAuthorship W4236057011A5048794978 @default.
• W4236057011 hasAuthorship W4236057011A5065646419 @default.
• W4236057011 hasAuthorship W4236057011A5068602145 @default.
• W4236057011 hasAuthorship W4236057011A5082881860 @default.
• W4236057011 hasAuthorship W4236057011A5082963441 @default.
• W4236057011 hasBestOaLocation W42360570111 @default.
• W4236057011 hasConcept C104317684 @default.
• W4236057011 hasConcept C10515644 @default.
• W4236057011 hasConcept C126322002 @default.
• W4236057011 hasConcept C143998085 @default.
• W4236057011 hasConcept C2776256026 @default.
• W4236057011 hasConcept C502942594 @default.
• W4236057011 hasConcept C54355233 @default.
• W4236057011 hasConcept C70721500 @default.
• W4236057011 hasConcept C71924100 @default.
• W4236057011 hasConcept C86803240 @default.
• W4236057011 hasConceptScore W4236057011C104317684 @default.
• W4236057011 hasConceptScore W4236057011C10515644 @default.
• W4236057011 hasConceptScore W4236057011C126322002 @default.
• W4236057011 hasConceptScore W4236057011C143998085 @default.
• W4236057011 hasConceptScore W4236057011C2776256026 @default.
• W4236057011 hasConceptScore W4236057011C502942594 @default.
• W4236057011 hasConceptScore W4236057011C54355233 @default.
• W4236057011 hasConceptScore W4236057011C70721500 @default.
• W4236057011 hasConceptScore W4236057011C71924100 @default.
• W4236057011 hasConceptScore W4236057011C86803240 @default.
• W4236057011 hasLocation W42360570111 @default.
• W4236057011 hasLocation W42360570112 @default.
• W4236057011 hasLocation W42360570113 @default.
• W4236057011 hasOpenAccess W4236057011 @default.
• W4236057011 hasPrimaryLocation W42360570111 @default.
• W4236057011 hasRelatedWork W1090245 @default.
• W4236057011 hasRelatedWork W13056427 @default.
• W4236057011 hasRelatedWork W16737275 @default.
• W4236057011 hasRelatedWork W17414462 @default.
• W4236057011 hasRelatedWork W18766104 @default.
• W4236057011 hasRelatedWork W20992803 @default.
• W4236057011 hasRelatedWork W22582601 @default.
• W4236057011 hasRelatedWork W29894752 @default.
• W4236057011 hasRelatedWork W6834028 @default.
• W4236057011 hasRelatedWork W8353733 @default.
• W4236057011 isParatext "false" @default.
• W4236057011 isRetracted "false" @default.
• W4236057011 workType "article" @default.