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- W4236057424 abstract "Abstract Recent experimental work has suggested that the adrenergic nervous system is important in regulating cerebral blood flow under conditions of hypoxia and systemic arterial hypertension. Although previous investigations have demonstrated the presence of adrenergic neurons adjacent to human cerebral vessels, the nature of adrenergic receptors on human cerebral blood vessels remains poorly defined. The present study was performed to characterize adrenergic reception on membranes prepared from human pia, a rich source of small blood vessels, using radioligand binding techniques. Adrenergic membrane receptors were characterized using the binding of [3H]dihydroalprenolol for the B subtypes and [3H]prazosin and [3H]yohimbine for the A subtypes. Displaceable binding was demonstrated with each agent. A small series of adrenergic agents competed for the [3H]dihydroalprenolol, [3H]yohimbine, and [3H]praz binding sites in a fashion suggesting the presence of A1-, A2-, B1and B2-receptors on the vessels within human pia." @default.
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- W4236057424 date "1990-07-01" @default.
- W4236057424 modified "2023-09-23" @default.
- W4236057424 title "The Identification of Adrenergic Receptors in Human Pial Membranes" @default.
- W4236057424 doi "https://doi.org/10.1227/00006123-199007000-00007" @default.
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