Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236059539> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4236059539 endingPage "1883" @default.
- W4236059539 startingPage "1875" @default.
- W4236059539 abstract "The effects of recombinant, macrophage-derived, murine tumor necrosis factor-alpha (TNF-alpha) on hematopoiesis in vivo has been examined in normal mice and in Friend virus (FV)-induced erythroleukemic mice. Intravenous (IV) administration of a single dose of recombinant murine TNF-alpha (10(5) U per mouse) significantly suppressed normal and leukemic late-stage erythropoiesis as measured by numbers of mature erythroid colony forming cells (CFU-E) in the bone marrow and spleen and by peripheral blood reticulocyte counts. In normal animals, the immature erythroid (BFU-E), macrophage (CFU-M), and granulocyte- macrophage (CFU-GM) compartments were significantly stimulated by TNF- alpha in both the bone marrow and the spleen. In the bone marrow of leukemic mice, the BFU-E, CFU-GM, and CFU-M progenitor cell compartments were also stimulated by treatment with the monokine. In the spleens of leukemic mice (the primary site of FV leukemia cell accumulation), relative numbers of BFU-E and CFU-GM were increased by TNF-alpha, while those of CFU-M were suppressed. TNF-alpha caused a rapid decrease in the markedly elevated spleen weights of progressively leukemic mice, and in multiple doses it caused complete clinical disease regression in a significant percentage of leukemic animals. The combination of TNF-alpha with interferon-gamma (IFN-gamma) increased the incidence of leukemia regression, compared with TNF-alpha alone. These results show that TNF-alpha exerts a suppressive influence on late-stage erythropoiesis in vivo and suggest that this effect might be exploited in the treatment of acute erythroleukemia, erythroid hyperplasias, and related diseases." @default.
- W4236059539 created "2022-05-12" @default.
- W4236059539 creator A5014753907 @default.
- W4236059539 creator A5035080887 @default.
- W4236059539 creator A5039856693 @default.
- W4236059539 date "1988-12-01" @default.
- W4236059539 modified "2023-10-03" @default.
- W4236059539 title "In vivo hematopoietic effects of tumor necrosis factor-alpha in normal and erythroleukemic mice: characterization and therapeutic applications" @default.
- W4236059539 doi "https://doi.org/10.1182/blood.v72.6.1875.bloodjournal7261875" @default.
- W4236059539 hasPublicationYear "1988" @default.
- W4236059539 type Work @default.
- W4236059539 citedByCount "0" @default.
- W4236059539 crossrefType "journal-article" @default.
- W4236059539 hasAuthorship W4236059539A5014753907 @default.
- W4236059539 hasAuthorship W4236059539A5035080887 @default.
- W4236059539 hasAuthorship W4236059539A5039856693 @default.
- W4236059539 hasBestOaLocation W42360595391 @default.
- W4236059539 hasConcept C109159458 @default.
- W4236059539 hasConcept C126322002 @default.
- W4236059539 hasConcept C134018914 @default.
- W4236059539 hasConcept C150903083 @default.
- W4236059539 hasConcept C17991360 @default.
- W4236059539 hasConcept C201750760 @default.
- W4236059539 hasConcept C203014093 @default.
- W4236059539 hasConcept C207001950 @default.
- W4236059539 hasConcept C2778248108 @default.
- W4236059539 hasConcept C2778461978 @default.
- W4236059539 hasConcept C2778690821 @default.
- W4236059539 hasConcept C2779603739 @default.
- W4236059539 hasConcept C2779703530 @default.
- W4236059539 hasConcept C2780007613 @default.
- W4236059539 hasConcept C2780931953 @default.
- W4236059539 hasConcept C28328180 @default.
- W4236059539 hasConcept C54355233 @default.
- W4236059539 hasConcept C71924100 @default.
- W4236059539 hasConcept C74172505 @default.
- W4236059539 hasConcept C86803240 @default.
- W4236059539 hasConceptScore W4236059539C109159458 @default.
- W4236059539 hasConceptScore W4236059539C126322002 @default.
- W4236059539 hasConceptScore W4236059539C134018914 @default.
- W4236059539 hasConceptScore W4236059539C150903083 @default.
- W4236059539 hasConceptScore W4236059539C17991360 @default.
- W4236059539 hasConceptScore W4236059539C201750760 @default.
- W4236059539 hasConceptScore W4236059539C203014093 @default.
- W4236059539 hasConceptScore W4236059539C207001950 @default.
- W4236059539 hasConceptScore W4236059539C2778248108 @default.
- W4236059539 hasConceptScore W4236059539C2778461978 @default.
- W4236059539 hasConceptScore W4236059539C2778690821 @default.
- W4236059539 hasConceptScore W4236059539C2779603739 @default.
- W4236059539 hasConceptScore W4236059539C2779703530 @default.
- W4236059539 hasConceptScore W4236059539C2780007613 @default.
- W4236059539 hasConceptScore W4236059539C2780931953 @default.
- W4236059539 hasConceptScore W4236059539C28328180 @default.
- W4236059539 hasConceptScore W4236059539C54355233 @default.
- W4236059539 hasConceptScore W4236059539C71924100 @default.
- W4236059539 hasConceptScore W4236059539C74172505 @default.
- W4236059539 hasConceptScore W4236059539C86803240 @default.
- W4236059539 hasIssue "6" @default.
- W4236059539 hasLocation W42360595391 @default.
- W4236059539 hasOpenAccess W4236059539 @default.
- W4236059539 hasPrimaryLocation W42360595391 @default.
- W4236059539 hasRelatedWork W11445608 @default.
- W4236059539 hasRelatedWork W15165260 @default.
- W4236059539 hasRelatedWork W18409229 @default.
- W4236059539 hasRelatedWork W18629846 @default.
- W4236059539 hasRelatedWork W19814619 @default.
- W4236059539 hasRelatedWork W20008175 @default.
- W4236059539 hasRelatedWork W6509916 @default.
- W4236059539 hasRelatedWork W7054843 @default.
- W4236059539 hasRelatedWork W767396 @default.
- W4236059539 hasRelatedWork W8292722 @default.
- W4236059539 hasVolume "72" @default.
- W4236059539 isParatext "false" @default.
- W4236059539 isRetracted "false" @default.
- W4236059539 workType "article" @default.