FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236064830> ?p ?o ?g. }

• W4236064830 endingPage "568" @default.
• W4236064830 startingPage "564" @default.
• W4236064830 abstract "Using a rabbit model of intracranial hypertension, we studied (a) the additive effect of propofol and hyperventilation (HV) on increased intracranial pressure (ICP), (b) the ICP-lowering effect of additive therapy (i.e., propofol plus HV versus HV plus propofol), and (c) whether combined therapy induced cerebral ischemia. Twenty-three New Zealand White rabbits were studied, of which seven were control animals. The animals were anesthetized with midazolam and fentanyl. An extradural balloon was used to increase ICP to 26 +/- 2 mm Hg. Elevation of ICP resulted in a >50% reduction in ipsilateral somatosensory evoked potential (SEP) amplitude. The rabbits were then randomized to be treated with propofol followed by HV (Group 1, n = 8) or HV then propofol (Group 2, n = 8). With HV, PaCO2 was reduced from 41 +/- 2 mm Hg to 27 +/- 3 mm Hg. In Group 1 rabbits, the ICP decreased with treatment (from 26 +/- 2 to 12 +/- 2 mm Hg). The reduction in ICP was significantly greater (P = 0.008) than that in Group 2 rabbits (from 26 +/- 2 to 16 +/- 5 mm Hg). In both groups, propofol and HV had an additive effect in reducing ICP. Further, when propofol was used as the initial treatment, there was a significant increase in SEP amplitude that was not apparent in Group 2 rabbits. In conclusion, we found propofol and HV to be additive in the treatment of increased ICP. In animals treated with propofol followed by HV, there was a greater decrease in ICP than in rabbits treated initially with HV and then propofol. Implications: We have demonstrated that propofol has a greater effect on increased intracranial pressure than hyperventilation when used as the initial treatment and that the two treatments are additive. Should control of intracranial pressure be required after the administration of propofol, then hyperventilation may be added to the treatment. (Anesth Analg 1998;87:564-8)" @default.
• W4236064830 created "2022-05-12" @default.
• W4236064830 creator A5018472971 @default.
• W4236064830 creator A5040357508 @default.
• W4236064830 creator A5067086470 @default.
• W4236064830 date "1998-09-01" @default.
• W4236064830 modified "2023-10-03" @default.
• W4236064830 title "Propofol and Hyperventilation for the Treatment of Increased Intracranial Pressure in Rabbits" @default.
• W4236064830 cites W1511774167 @default.
• W4236064830 cites W1971155651 @default.
• W4236064830 cites W1977708752 @default.
• W4236064830 cites W1992683546 @default.
• W4236064830 cites W1995031448 @default.
• W4236064830 cites W2005067965 @default.
• W4236064830 cites W2026492597 @default.
• W4236064830 cites W2058267482 @default.
• W4236064830 cites W2058319239 @default.
• W4236064830 cites W2065408464 @default.
• W4236064830 cites W2066446873 @default.
• W4236064830 cites W2069463720 @default.
• W4236064830 cites W2072527565 @default.
• W4236064830 cites W2089463832 @default.
• W4236064830 cites W2109095295 @default.
• W4236064830 cites W2124913096 @default.
• W4236064830 cites W2131235455 @default.
• W4236064830 cites W2165499048 @default.
• W4236064830 cites W2171906554 @default.
• W4236064830 cites W2440650944 @default.
• W4236064830 cites W4231717353 @default.
• W4236064830 doi "https://doi.org/10.1213/00000539-199809000-00012" @default.
• W4236064830 hasPublicationYear "1998" @default.
• W4236064830 type Work @default.
• W4236064830 citedByCount "13" @default.
• W4236064830 countsByYear W42360648302012 @default.
• W4236064830 countsByYear W42360648302014 @default.
• W4236064830 countsByYear W42360648302015 @default.
• W4236064830 crossrefType "journal-article" @default.
• W4236064830 hasAuthorship W4236064830A5018472971 @default.
• W4236064830 hasAuthorship W4236064830A5040357508 @default.
• W4236064830 hasAuthorship W4236064830A5067086470 @default.
• W4236064830 hasConcept C2776277131 @default.
• W4236064830 hasConcept C2776814716 @default.
• W4236064830 hasConcept C2777449187 @default.
• W4236064830 hasConcept C2778000748 @default.
• W4236064830 hasConcept C2780954326 @default.
• W4236064830 hasConcept C2781072394 @default.
• W4236064830 hasConcept C42219234 @default.
• W4236064830 hasConcept C71924100 @default.
• W4236064830 hasConceptScore W4236064830C2776277131 @default.
• W4236064830 hasConceptScore W4236064830C2776814716 @default.
• W4236064830 hasConceptScore W4236064830C2777449187 @default.
• W4236064830 hasConceptScore W4236064830C2778000748 @default.
• W4236064830 hasConceptScore W4236064830C2780954326 @default.
• W4236064830 hasConceptScore W4236064830C2781072394 @default.
• W4236064830 hasConceptScore W4236064830C42219234 @default.
• W4236064830 hasConceptScore W4236064830C71924100 @default.
• W4236064830 hasIssue "3" @default.
• W4236064830 hasLocation W42360648301 @default.
• W4236064830 hasOpenAccess W4236064830 @default.
• W4236064830 hasPrimaryLocation W42360648301 @default.
• W4236064830 hasRelatedWork W1488705246 @default.
• W4236064830 hasRelatedWork W1510664945 @default.
• W4236064830 hasRelatedWork W1543982038 @default.
• W4236064830 hasRelatedWork W2083750369 @default.
• W4236064830 hasRelatedWork W2348989627 @default.
• W4236064830 hasRelatedWork W2357312537 @default.
• W4236064830 hasRelatedWork W2361468386 @default.
• W4236064830 hasRelatedWork W248794154 @default.
• W4236064830 hasRelatedWork W3089058398 @default.
• W4236064830 hasRelatedWork W3030500103 @default.
• W4236064830 hasVolume "87" @default.
• W4236064830 isParatext "false" @default.
• W4236064830 isRetracted "false" @default.
• W4236064830 workType "article" @default.