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- W4236065088 abstract "Ciprofloxacin (CIP) (human use) and enrofloxacin (ENR) (veterinary use) are synthetic anti-infectious medications that belong to the second generation of fluoroquinolones. They have a wide antimicrobial spectrum and strong bactericidal effects at very low concentrations via enzymatic inhibition of DNA gyrase and topoisomerase IV, which are required for DNA replication. They also have high bioavailability, rapid absorption with favorable pharmacokinetics and excellent tissue penetration, including cerebral spinal fluid. These features have made them the most applied antibiotics in both human and veterinary medicine. ENR is marketed exclusively for animal medicine and has been widely used as a therapeutic veterinary antibiotic, resulting in its residue in edible tissues and aquatic environments, as well as the development of resistance and toxicity. Estimation of the risks to humans due to antimicrobial resistance produced by CIP and ENR is important and of great interest. Moreover, in rare cases due to their overdose and/or prolonged administration, the development of CIP and ENR toxicity may occur. The toxicity of these fluoroquinolones antimicrobials is mainly related to reactive oxygen species (ROS) and oxidative stress (OS) generation, besides metabolism-related toxicity. Therefore, CIP is restricted in pregnant and lactating women, pediatrics and elderly similarly ENR do in the veterinary field. This review manuscript aims to identify the toxicity induced by ROS and OS as a common sequel of CIP and ENR. Furthermore, their metabolism and the role of metabolizing enzymes were reported." @default.
- W4236065088 created "2022-05-12" @default.
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- W4236065088 date "2021-10-21" @default.
- W4236065088 modified "2023-10-13" @default.
- W4236065088 title "Toxicity induced by ciprofloxacin and enrofloxacin: oxidative stress and metabolism" @default.
- W4236065088 cites W101997918 @default.
- W4236065088 cites W124822842 @default.
- W4236065088 cites W145636110 @default.
- W4236065088 cites W1481302344 @default.
- W4236065088 cites W1540122390 @default.
- W4236065088 cites W1562736322 @default.
- W4236065088 cites W1589502475 @default.
- W4236065088 cites W1590490318 @default.
- W4236065088 cites W1650275048 @default.
- W4236065088 cites W1654757531 @default.
- W4236065088 cites W1832672712 @default.
- W4236065088 cites W1854912876 @default.
- W4236065088 cites W1882497924 @default.
- W4236065088 cites W1906360081 @default.
- W4236065088 cites W1930556898 @default.
- W4236065088 cites W1931915352 @default.
- W4236065088 cites W1964790676 @default.
- W4236065088 cites W1966169035 @default.
- W4236065088 cites W1966303791 @default.
- W4236065088 cites W1969141242 @default.
- W4236065088 cites W1969443770 @default.
- W4236065088 cites W1969445695 @default.
- W4236065088 cites W1970086938 @default.
- W4236065088 cites W1972006241 @default.
- W4236065088 cites W1972455042 @default.
- W4236065088 cites W1972517702 @default.
- W4236065088 cites W1973719115 @default.
- W4236065088 cites W1973910115 @default.
- W4236065088 cites W1975590710 @default.
- W4236065088 cites W1975788163 @default.
- W4236065088 cites W1975920057 @default.
- W4236065088 cites W1977927277 @default.
- W4236065088 cites W1978050498 @default.
- W4236065088 cites W1978351154 @default.
- W4236065088 cites W1981880543 @default.
- W4236065088 cites W1983392438 @default.
- W4236065088 cites W1983411620 @default.
- W4236065088 cites W1986391515 @default.
- W4236065088 cites W1986811480 @default.
- W4236065088 cites W1988199149 @default.
- W4236065088 cites W1991430505 @default.
- W4236065088 cites W1991724171 @default.
- W4236065088 cites W1991905759 @default.
- W4236065088 cites W1992015232 @default.
- W4236065088 cites W1993019119 @default.
- W4236065088 cites W1993122399 @default.
- W4236065088 cites W1994972456 @default.
- W4236065088 cites W1997571854 @default.
- W4236065088 cites W1997815372 @default.
- W4236065088 cites W2000570357 @default.
- W4236065088 cites W2004071666 @default.
- W4236065088 cites W2005091356 @default.
- W4236065088 cites W2007858375 @default.
- W4236065088 cites W2007997441 @default.
- W4236065088 cites W2009119563 @default.
- W4236065088 cites W2009296897 @default.
- W4236065088 cites W2010099631 @default.
- W4236065088 cites W2010305622 @default.
- W4236065088 cites W2010427019 @default.
- W4236065088 cites W2012279192 @default.
- W4236065088 cites W2014635584 @default.
- W4236065088 cites W2021273259 @default.
- W4236065088 cites W2022184505 @default.
- W4236065088 cites W2023584161 @default.
- W4236065088 cites W2031223726 @default.
- W4236065088 cites W2032222317 @default.
- W4236065088 cites W2036262011 @default.
- W4236065088 cites W2036876016 @default.
- W4236065088 cites W2038687954 @default.
- W4236065088 cites W2039058800 @default.
- W4236065088 cites W2039510798 @default.
- W4236065088 cites W2041858240 @default.
- W4236065088 cites W2042204000 @default.
- W4236065088 cites W2042218856 @default.
- W4236065088 cites W2044324738 @default.
- W4236065088 cites W2046425627 @default.
- W4236065088 cites W2046548856 @default.
- W4236065088 cites W2048413661 @default.
- W4236065088 cites W2048486012 @default.
- W4236065088 cites W2052800989 @default.
- W4236065088 cites W2054937281 @default.
- W4236065088 cites W2055958560 @default.
- W4236065088 cites W2057863993 @default.