Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236066684> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4236066684 endingPage "tw330" @default.
- W4236066684 startingPage "tw330" @default.
- W4236066684 abstract "Neurofibrillary tangles, which contain a phosphorylated form of the microtubule-binding protein tau, and amyloid plaques, which contain the β-amyloid peptide Aβ1-42, are common in the brains of Alzheimer's disease patients. Wang et al. showed that cells that express α7 nicotinic acetylcholine receptors (α7nAChRs) exhibit a dose-dependent Aβ1-42 stimulation of tau phosphorylation at all three residues commonly phosphorylated in tau found in neurofibrillary tangles. Specifically, cortical and hippocampal synaptosomes and human neuroblastoma SK-N-MC cells responded to Aβ1-42, whereas cells that did not express α7nAChRs, human Bowes melanoma cells and rat striatum synaptosomes, did not exhibit increased tau phosphorylation. The stimulation of tau phosphorylation was only observed in response to the Aβ1-42 fragment and not other fragments of Aβ. Furthermore, tau phosphorylation in response to Aβ1-42 was inhibited by pharmacological treatments that selectively blocked α7nAChRs or inhibition of α7nAChR expression by oligonucleotide antisense treatment. Interestingly, Aβ1-42 exhibits inhibitory activity toward α7nAChR with respect to calcium mobilization and acetylcholine release; however, Wang et al. reported that Aβ1-42 stimulated extracellular signal-regulated kinases 1 and 2 (ERK1/2) and c-Jun N-terminal kinase 1 (JNK-1). Furthermore, stimulation of these kinases was inhibited by antisense oligonucleotide treatment to decrease α7nAChR. JNK-1 and ERK1/2 were able to phosphorylate tau in vitro. Thus, Aβ1-42 may contribute to tau phosphorylation through an α7nAChR pathway, further supporting a role for α7nAChRs in Alzheimer's disease progression. H.-Y. Wang, W. Li, N. J. Benedetti, D. H. S. Lee, α7 Nicotinic acetylcholine receptors mediate β-amyloid peptide-induced tau protein phosphorylation. J. Biol. Chem. 278, 31547-31553 (2003).[Abstract][Full Text]" @default.
- W4236066684 created "2022-05-12" @default.
- W4236066684 date "2003-08-26" @default.
- W4236066684 modified "2023-09-30" @default.
- W4236066684 title "A Role for Nicotinic Acetylcholine Receptors in Alzheimer's Disease" @default.
- W4236066684 doi "https://doi.org/10.1126/scisignal.1972003tw330" @default.
- W4236066684 hasPublicationYear "2003" @default.
- W4236066684 type Work @default.
- W4236066684 citedByCount "0" @default.
- W4236066684 crossrefType "journal-article" @default.
- W4236066684 hasConcept C11960822 @default.
- W4236066684 hasConcept C126322002 @default.
- W4236066684 hasConcept C134018914 @default.
- W4236066684 hasConcept C153911025 @default.
- W4236066684 hasConcept C169760540 @default.
- W4236066684 hasConcept C170493617 @default.
- W4236066684 hasConcept C184235292 @default.
- W4236066684 hasConcept C185592680 @default.
- W4236066684 hasConcept C22885893 @default.
- W4236066684 hasConcept C24998067 @default.
- W4236066684 hasConcept C2775910092 @default.
- W4236066684 hasConcept C2778670691 @default.
- W4236066684 hasConcept C2779134260 @default.
- W4236066684 hasConcept C502032728 @default.
- W4236066684 hasConcept C55493867 @default.
- W4236066684 hasConcept C68026918 @default.
- W4236066684 hasConcept C71924100 @default.
- W4236066684 hasConcept C80161118 @default.
- W4236066684 hasConcept C86803240 @default.
- W4236066684 hasConcept C95444343 @default.
- W4236066684 hasConceptScore W4236066684C11960822 @default.
- W4236066684 hasConceptScore W4236066684C126322002 @default.
- W4236066684 hasConceptScore W4236066684C134018914 @default.
- W4236066684 hasConceptScore W4236066684C153911025 @default.
- W4236066684 hasConceptScore W4236066684C169760540 @default.
- W4236066684 hasConceptScore W4236066684C170493617 @default.
- W4236066684 hasConceptScore W4236066684C184235292 @default.
- W4236066684 hasConceptScore W4236066684C185592680 @default.
- W4236066684 hasConceptScore W4236066684C22885893 @default.
- W4236066684 hasConceptScore W4236066684C24998067 @default.
- W4236066684 hasConceptScore W4236066684C2775910092 @default.
- W4236066684 hasConceptScore W4236066684C2778670691 @default.
- W4236066684 hasConceptScore W4236066684C2779134260 @default.
- W4236066684 hasConceptScore W4236066684C502032728 @default.
- W4236066684 hasConceptScore W4236066684C55493867 @default.
- W4236066684 hasConceptScore W4236066684C68026918 @default.
- W4236066684 hasConceptScore W4236066684C71924100 @default.
- W4236066684 hasConceptScore W4236066684C80161118 @default.
- W4236066684 hasConceptScore W4236066684C86803240 @default.
- W4236066684 hasConceptScore W4236066684C95444343 @default.
- W4236066684 hasIssue "197" @default.
- W4236066684 hasLocation W42360666841 @default.
- W4236066684 hasOpenAccess W4236066684 @default.
- W4236066684 hasPrimaryLocation W42360666841 @default.
- W4236066684 hasRelatedWork W1966766929 @default.
- W4236066684 hasRelatedWork W1967171783 @default.
- W4236066684 hasRelatedWork W1988615846 @default.
- W4236066684 hasRelatedWork W2023542089 @default.
- W4236066684 hasRelatedWork W2037602724 @default.
- W4236066684 hasRelatedWork W2088034288 @default.
- W4236066684 hasRelatedWork W2147004190 @default.
- W4236066684 hasRelatedWork W2470152517 @default.
- W4236066684 hasRelatedWork W4212801181 @default.
- W4236066684 hasRelatedWork W4246600328 @default.
- W4236066684 hasVolume "2003" @default.
- W4236066684 isParatext "false" @default.
- W4236066684 isRetracted "false" @default.
- W4236066684 workType "article" @default.