Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236075707> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4236075707 endingPage "256" @default.
- W4236075707 startingPage "249" @default.
- W4236075707 abstract "We have studied the influence of the oral administration of excess copper (Cu) on the immune response. With this aim, mice maintained on standard laboratory diet received 50, 100, 200, or 300 ppm of Cu as copper sulfate in the drinking water during 3 to 10 weeks. Inhibition of the proliferative response to concanavalin A was observed in mice exposed to 100 ppm of Cu for 8 weeks and to 200 ppm of Cu for either 3 or 8 weeks. Conversely, a significant increase in the proliferative response to Eschenchia colilipopolysaccharide (LPS) was observed in mice exposed to 50 or 100 ppm of Cu for 3 weeks. However, the response to LPS was also significantly inhibited following prolonged Cu administration. In contrast, mice exposed to low or high Cu doses during short or long periods showed increased production of autoantibodies directed to bromelain-treated mouse erythrocytes. The DTH response to sheep red blood cells was not modified following short-term administration of 100 ppm of Cu, but was depressed after prolonged exposure to this dose of the metal. Significant inhibition of the DTH response was observed in mice exposed to 300 ppm of Cu for 5 or 10 weeks. Thus, oral administration of excess Cu altered the immune response in a fashion related to the dose and duration of treatment" @default.
- W4236075707 created "2022-05-12" @default.
- W4236075707 creator A5007722748 @default.
- W4236075707 creator A5025390036 @default.
- W4236075707 creator A5040965274 @default.
- W4236075707 date "1991-01-01" @default.
- W4236075707 modified "2023-10-03" @default.
- W4236075707 title "Influence of the Oral Administration of Excess Copper on the Immune Response" @default.
- W4236075707 doi "https://doi.org/10.1093/toxsci/16.2.249" @default.
- W4236075707 hasPublicationYear "1991" @default.
- W4236075707 type Work @default.
- W4236075707 citedByCount "4" @default.
- W4236075707 countsByYear W42360757072012 @default.
- W4236075707 countsByYear W42360757072016 @default.
- W4236075707 crossrefType "journal-article" @default.
- W4236075707 hasAuthorship W4236075707A5007722748 @default.
- W4236075707 hasAuthorship W4236075707A5025390036 @default.
- W4236075707 hasAuthorship W4236075707A5040965274 @default.
- W4236075707 hasConcept C126322002 @default.
- W4236075707 hasConcept C134018914 @default.
- W4236075707 hasConcept C178790620 @default.
- W4236075707 hasConcept C185592680 @default.
- W4236075707 hasConcept C19869320 @default.
- W4236075707 hasConcept C202751555 @default.
- W4236075707 hasConcept C203014093 @default.
- W4236075707 hasConcept C2777056448 @default.
- W4236075707 hasConcept C2777928079 @default.
- W4236075707 hasConcept C2993457186 @default.
- W4236075707 hasConcept C544778455 @default.
- W4236075707 hasConcept C55493867 @default.
- W4236075707 hasConcept C71924100 @default.
- W4236075707 hasConcept C79410662 @default.
- W4236075707 hasConcept C8891405 @default.
- W4236075707 hasConcept C98274493 @default.
- W4236075707 hasConceptScore W4236075707C126322002 @default.
- W4236075707 hasConceptScore W4236075707C134018914 @default.
- W4236075707 hasConceptScore W4236075707C178790620 @default.
- W4236075707 hasConceptScore W4236075707C185592680 @default.
- W4236075707 hasConceptScore W4236075707C19869320 @default.
- W4236075707 hasConceptScore W4236075707C202751555 @default.
- W4236075707 hasConceptScore W4236075707C203014093 @default.
- W4236075707 hasConceptScore W4236075707C2777056448 @default.
- W4236075707 hasConceptScore W4236075707C2777928079 @default.
- W4236075707 hasConceptScore W4236075707C2993457186 @default.
- W4236075707 hasConceptScore W4236075707C544778455 @default.
- W4236075707 hasConceptScore W4236075707C55493867 @default.
- W4236075707 hasConceptScore W4236075707C71924100 @default.
- W4236075707 hasConceptScore W4236075707C79410662 @default.
- W4236075707 hasConceptScore W4236075707C8891405 @default.
- W4236075707 hasConceptScore W4236075707C98274493 @default.
- W4236075707 hasIssue "2" @default.
- W4236075707 hasLocation W42360757071 @default.
- W4236075707 hasOpenAccess W4236075707 @default.
- W4236075707 hasPrimaryLocation W42360757071 @default.
- W4236075707 hasRelatedWork W1976766119 @default.
- W4236075707 hasRelatedWork W2023144730 @default.
- W4236075707 hasRelatedWork W2034306566 @default.
- W4236075707 hasRelatedWork W2055941401 @default.
- W4236075707 hasRelatedWork W2070185467 @default.
- W4236075707 hasRelatedWork W2089428561 @default.
- W4236075707 hasRelatedWork W2101207500 @default.
- W4236075707 hasRelatedWork W2124937646 @default.
- W4236075707 hasRelatedWork W2135342622 @default.
- W4236075707 hasRelatedWork W3022570814 @default.
- W4236075707 hasVolume "16" @default.
- W4236075707 isParatext "false" @default.
- W4236075707 isRetracted "false" @default.
- W4236075707 workType "article" @default.