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- W4236076316 abstract "The role of chromatin in mounting a synergistic transcriptional response to GAL4-VP16 was investigated. Strong synergy was observed when chromatin templates were used in vitro. The synergy was severely reduced when naked DNA templates were transcribed. In vivo synergy was strong when nonreplicating templates were used. However, the use of replicating templates, which involved transient disruptions of chromatin, led to strong reductions in synergy. In both of these low-synergy responses, transcription levels were high. We infer that strong synergy has a requirement for chromatin that may be understood in terms of the competition between multiple activator molecules and histone cores for promoter DNA." @default.
- W4236076316 created "2022-05-12" @default.
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- W4236076316 date "1994-08-01" @default.
- W4236076316 modified "2023-09-26" @default.
- W4236076316 title "A Critical Role for Chromatin in Mounting a Synergistic Transcriptional Response to GAL4-VP16" @default.
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- W4236076316 doi "https://doi.org/10.1128/mcb.14.8.5175-5181.1994" @default.
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