FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236081165> ?p ?o ?g. }

• W4236081165 endingPage "e19357" @default.
• W4236081165 startingPage "e19357" @default.
• W4236081165 abstract "Abstract Background: Vonoprazan is a potassium-competitive acid blocker (P-CAB) that is frequently used in Japan for Helicobacter pylori (H. pylori ) eradication, treatment of gastroesophageal reflux disease, and treatment of post endoscopic submucosal dissection (ESD) complications. We sought to determine if vonoprazan was superior to proton pump inhibitors (PPIs) for treating ESD-induced ulcers (as assessed by ulcer healing and shrinkage ratios) and preventing delayed bleeding over various treatment durations (2, 4, and 8 weeks). Methods: We collected randomized controlled trials (RCTs) and observational studies that discussed the effectiveness of vonoprazan and PPIs on ESD-induced ulcers and bleeding from PubMed, Cochrane Library, ClinicalTrials.gov, and Google Scholar. Studies were selected according to pre-established eligibility criteria and data were extracted separately by 2 researchers with double-check. We used the Cochrane risk of bias tool to assess RCTs and the Newcastle–Ottawa Quality Assessment Scale to assess observational studies. Meta-analyses, based on the random-effects model, were conducted to compare differences in ulcer shrinkage ratios (%) and odds ratios (ORs) for ulcer healing and delayed bleeding. Publication bias was evaluated using funnel plots and Egger regression test. Heterogeneity was assessed using I 2 statistics. A sensitivity analysis was conducted to check the robustness of results. The evidential quality of the findings was assessed using the GRADE profiler. Results: Thirteen studies were included in this meta-analysis. The OR effect sizes of vonoprazan relative to PPIs for ulcer healing were 1.33 ( P = .13) with a 95% CI (0.33–3.21) at 4 weeks and 1.48 ( P = .09) with a 95% CI (0.81–5.20) at 8 weeks. The overall effect size for the shrinkage ratio was 12.24% ( P = .16) with a 95% CI (−4.96–29.44) at 2 weeks. The effect size of its subgroup of H. pylori -positive patients was 19.51% ( P < .001) with a 95% CI (11.91–27.12). The overall OR for the occurrence of delayed bleeding was 0.66 ( P = .26) with a 95% CI (0.32–1.35). After excluding combination drug studies, the overall ORs between vonoprazan and PPIs on ulcer healing and delayed bleeding were 1.44 and 0.76, respectively. Conclusion: During the first 2 weeks of treatment, vonoprazan was more effective than PPIs for treating H. pylori -positive patients with ESD-induced gastric ulcers." @default.
• W4236081165 created "2022-05-12" @default.
• W4236081165 creator A5019686014 @default.
• W4236081165 creator A5045159088 @default.
• W4236081165 creator A5076573677 @default.
• W4236081165 creator A5080834542 @default.
• W4236081165 creator A5087772443 @default.
• W4236081165 date "2020-02-01" @default.
• W4236081165 modified "2023-10-03" @default.
• W4236081165 title "Vonoprazan vs proton pump inhibitors in treating post-endoscopic submucosal dissection ulcers and preventing bleeding" @default.
• W4236081165 cites W1972211289 @default.
• W4236081165 cites W2031584935 @default.
• W4236081165 cites W2041467176 @default.
• W4236081165 cites W2043323206 @default.
• W4236081165 cites W2056770708 @default.
• W4236081165 cites W2063920927 @default.
• W4236081165 cites W2090984340 @default.
• W4236081165 cites W2116475791 @default.
• W4236081165 cites W2125314163 @default.
• W4236081165 cites W2131652056 @default.
• W4236081165 cites W2134236426 @default.
• W4236081165 cites W2151867967 @default.
• W4236081165 cites W2156098321 @default.
• W4236081165 cites W2169205464 @default.
• W4236081165 cites W2301012193 @default.
• W4236081165 cites W246286872 @default.
• W4236081165 cites W2492840086 @default.
• W4236081165 cites W2516103798 @default.
• W4236081165 cites W2555206525 @default.
• W4236081165 cites W2592987351 @default.
• W4236081165 cites W2613485273 @default.
• W4236081165 cites W2744215644 @default.
• W4236081165 cites W2753033207 @default.
• W4236081165 cites W2774222399 @default.
• W4236081165 cites W2782592164 @default.
• W4236081165 cites W2793965036 @default.
• W4236081165 cites W2794240184 @default.
• W4236081165 cites W2804271046 @default.
• W4236081165 cites W2805398543 @default.
• W4236081165 cites W2810584369 @default.
• W4236081165 cites W2819750453 @default.
• W4236081165 cites W2889276814 @default.
• W4236081165 cites W2891208097 @default.
• W4236081165 cites W2912703731 @default.
• W4236081165 cites W2918216703 @default.
• W4236081165 cites W2919241379 @default.
• W4236081165 cites W2952756922 @default.
• W4236081165 cites W2989205246 @default.
• W4236081165 cites W4242151806 @default.
• W4236081165 cites W4294215472 @default.
• W4236081165 doi "https://doi.org/10.1097/md.0000000000019357" @default.
• W4236081165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32118778" @default.
• W4236081165 hasPublicationYear "2020" @default.
• W4236081165 type Work @default.
• W4236081165 citedByCount "11" @default.
• W4236081165 countsByYear W42360811652020 @default.
• W4236081165 countsByYear W42360811652021 @default.
• W4236081165 countsByYear W42360811652022 @default.
• W4236081165 countsByYear W42360811652023 @default.
• W4236081165 crossrefType "journal-article" @default.
• W4236081165 hasAuthorship W4236081165A5019686014 @default.
• W4236081165 hasAuthorship W4236081165A5045159088 @default.
• W4236081165 hasAuthorship W4236081165A5076573677 @default.
• W4236081165 hasAuthorship W4236081165A5080834542 @default.
• W4236081165 hasAuthorship W4236081165A5087772443 @default.
• W4236081165 hasBestOaLocation W42360811651 @default.
• W4236081165 hasConcept C126322002 @default.
• W4236081165 hasConcept C141071460 @default.
• W4236081165 hasConcept C156957248 @default.
• W4236081165 hasConcept C168563851 @default.
• W4236081165 hasConcept C23131810 @default.
• W4236081165 hasConcept C2776409635 @default.
• W4236081165 hasConcept C2776478404 @default.
• W4236081165 hasConcept C2780439572 @default.
• W4236081165 hasConcept C2781025758 @default.
• W4236081165 hasConcept C71924100 @default.
• W4236081165 hasConcept C90924648 @default.
• W4236081165 hasConcept C95190672 @default.
• W4236081165 hasConceptScore W4236081165C126322002 @default.
• W4236081165 hasConceptScore W4236081165C141071460 @default.
• W4236081165 hasConceptScore W4236081165C156957248 @default.
• W4236081165 hasConceptScore W4236081165C168563851 @default.
• W4236081165 hasConceptScore W4236081165C23131810 @default.
• W4236081165 hasConceptScore W4236081165C2776409635 @default.
• W4236081165 hasConceptScore W4236081165C2776478404 @default.
• W4236081165 hasConceptScore W4236081165C2780439572 @default.
• W4236081165 hasConceptScore W4236081165C2781025758 @default.
• W4236081165 hasConceptScore W4236081165C71924100 @default.
• W4236081165 hasConceptScore W4236081165C90924648 @default.
• W4236081165 hasConceptScore W4236081165C95190672 @default.
• W4236081165 hasIssue "9" @default.
• W4236081165 hasLocation W42360811651 @default.
• W4236081165 hasLocation W42360811652 @default.
• W4236081165 hasLocation W42360811653 @default.
• W4236081165 hasLocation W42360811654 @default.
• W4236081165 hasOpenAccess W4236081165 @default.
• W4236081165 hasPrimaryLocation W42360811651 @default.
• W4236081165 hasRelatedWork W2071995032 @default.

• next