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• W4236088301 abstract "The principal function of the exocrine pancreas is to deliver safely digestive enzymes to the intestine in order to break down food products there, thereby enabling them to be absorbed into the circulation. The most important secretory cell in the exocrine pancreas is the acinar cell, which manufactures the inactive pro-enzymes and stores them in the zymogen granules. When enzyme delivery is required, the acinar cells receive a signal in the form of either the neurotransmitter acetylcholine (ACh) released from parasympathetic nerve endings and/or the hormone cholecystokinin (CCK). Interacting with specific surface membrane receptors, signal transduction mechanisms are activated that generate intracellular Ca2+ liberating messengers releasing Ca2+ from intracellular stores. Secondarily, Ca2 + -permeable channels in the plasma membrane are opened allowing Ca2+ entry from the extracellular solution. Under physiologic conditions the cytosolic Ca2+ concentration changes evoked by ACh or CCK consist of repetitive short-lasting elevations mostly confined to the apical region where the zymogen granules are concentrated. This local rise in the cytosolic Ca2+ concentration triggers exocytosis of the granule content as well as opening up Cl- channels in the apical membrane and K+ channels in the apical part of the lateral membrane. These channel openings enable operation of Na+,K+,Cl- co-transport as well as increased turnover of the Na+/K+ pump across the basolateral membrane. The net result is uptake of Cl- across the basolateral membrane and secretion of Cl- across the apical membrane with Na + following through the leaky tight junctions. Water moves along with the salt both through the cell and through the so-called tight junctions. The Ca2 + -activated acinar fluid secretion is a vehicle for transport of the pro-enzymes into the duct system, where an additional ductal fluid secretion of a bicarbonate-rich solution will help wash the pro-enzymes into the gut where they become active digestive enzymes." @default.
• W4236088301 created "2022-05-12" @default.
• W4236088301 creator A5035216729 @default.
• W4236088301 date "2018-02-12" @default.
• W4236088301 modified "2023-10-14" @default.
• W4236088301 title "Physiology of Acinar Cell Secretion" @default.
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• W4236088301 doi "https://doi.org/10.1002/9781119188421.ch4" @default.
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