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- W4236088783 abstract "Paliperidone is the primary active metabolite of the older antipsychotic risperidone, and is used to treat mania, bipolar disorder, and schizophrenia. The human metabolism of [ 14 C]‐paliperidone was examined in five healthy male subjects after an oral administration of 1 mg paliperidone solution. Unchanged parent was the only component detected in the plasma. Approximately 80% and 11% of the radioactivity was excreted in urine and in feces. About 59% of the dose was excreted as the parent drug in urine, and no parent drug was excreted in feces. Major metabolic reactions were N‐dealkylation, monohydroxylation of the alicyclic ring, and alcohol dehydrogenation. Benzisoxazole ring scission and monohydroxylation metabolites were also identified in feces. Phase II reaction was also important, yielding glucuronide conjugates of the hydroxylated metabolites." @default.
- W4236088783 created "2022-05-12" @default.
- W4236088783 creator A5060002817 @default.
- W4236088783 date "2013-10-13" @default.
- W4236088783 modified "2023-09-27" @default.
- W4236088783 title "Paliperidone" @default.
- W4236088783 cites W2127872656 @default.
- W4236088783 doi "https://doi.org/10.1002/9781118541203.xen525" @default.
- W4236088783 hasPublicationYear "2013" @default.
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