FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236098219> ?p ?o ?g. }

• W4236098219 endingPage "321" @default.
• W4236098219 startingPage "315" @default.
• W4236098219 abstract "Autoimmune gastritis is a chronic gastritis that may remain asymptomatic for many years before progression to gastric atrophy, depletion of stocks of vitamin B12 with clinical manifestations of pernicious anemia. Autoantibodies to gastric parietal cells, the molecular target of which is the gastric H/K ATPase, is the simplest screening test for autoimmune gastritis. Intrinsic factor autoantibodies, the second autoantibody test, typically segregate with the development of pernicious anemia; these antibodies have two actions – inhibition of vitamin B12 binding with intrinsic factor in the stomach and prevention of its transport into the body via the terminal ileum. Autoantibodies to gastric parietal cells and to intrinsic factor are present in 90 and 70%, respectively, of patients with pernicious anemia. As the gastritis evolves, the histology of the stomach shows increasing infiltration by lymphocytes accompanied by increasing destruction of parietal cells and zymogenic cells until the loss of mature cells is complete, the mucosa is atrophic, and there is intestinal metaplasia. This histologic evolution is accompanied by biochemical changes: loss of acid, depletion of pepsinogen I, and increased secretion of gastrin by the gastric antrum. Finally, when the stocks of vitamin B12 are exhausted, clinical and hematologic signs of megaloblastic anemia and its complications become evident. Although immunosuppressive drugs will check the autoimmune reaction allowing maturation of gastric parietal cells, the preferred treatment is vitamin B12 replacement." @default.
• W4236098219 created "2022-05-12" @default.
• W4236098219 creator A5016496408 @default.
• W4236098219 creator A5040452583 @default.
• W4236098219 creator A5042411420 @default.
• W4236098219 date "2008-01-01" @default.
• W4236098219 modified "2023-09-28" @default.
• W4236098219 title "Autoimmune Gastritis" @default.
• W4236098219 cites W1421760985 @default.
• W4236098219 cites W1965859896 @default.
• W4236098219 cites W1973329998 @default.
• W4236098219 cites W1985271366 @default.
• W4236098219 cites W1997140472 @default.
• W4236098219 cites W2006272907 @default.
• W4236098219 cites W2006611589 @default.
• W4236098219 cites W2009340688 @default.
• W4236098219 cites W2016063629 @default.
• W4236098219 cites W2016743510 @default.
• W4236098219 cites W2027447667 @default.
• W4236098219 cites W2035657327 @default.
• W4236098219 cites W2059574805 @default.
• W4236098219 cites W2065286513 @default.
• W4236098219 cites W2065718446 @default.
• W4236098219 cites W2093069204 @default.
• W4236098219 cites W2108184976 @default.
• W4236098219 cites W2119369015 @default.
• W4236098219 cites W2147827755 @default.
• W4236098219 cites W2167574472 @default.
• W4236098219 cites W2167665672 @default.
• W4236098219 cites W4233226444 @default.
• W4236098219 cites W4237386550 @default.
• W4236098219 cites W4240774372 @default.
• W4236098219 doi "https://doi.org/10.1007/978-1-60327-285-8_59" @default.
• W4236098219 hasPublicationYear "2008" @default.
• W4236098219 type Work @default.
• W4236098219 citedByCount "1" @default.
• W4236098219 countsByYear W42360982192016 @default.
• W4236098219 crossrefType "book-chapter" @default.
• W4236098219 hasAuthorship W4236098219A5016496408 @default.
• W4236098219 hasAuthorship W4236098219A5040452583 @default.
• W4236098219 hasAuthorship W4236098219A5042411420 @default.
• W4236098219 hasConcept C126322002 @default.
• W4236098219 hasConcept C159654299 @default.
• W4236098219 hasConcept C163764329 @default.
• W4236098219 hasConcept C203014093 @default.
• W4236098219 hasConcept C2775916456 @default.
• W4236098219 hasConcept C2776986829 @default.
• W4236098219 hasConcept C2777569460 @default.
• W4236098219 hasConcept C2778248108 @default.
• W4236098219 hasConcept C2778677798 @default.
• W4236098219 hasConcept C2779422922 @default.
• W4236098219 hasConcept C2779743957 @default.
• W4236098219 hasConcept C2779750884 @default.
• W4236098219 hasConcept C2779970781 @default.
• W4236098219 hasConcept C2780342937 @default.
• W4236098219 hasConcept C2780439177 @default.
• W4236098219 hasConcept C2781443798 @default.
• W4236098219 hasConcept C2910396959 @default.
• W4236098219 hasConcept C3017897077 @default.
• W4236098219 hasConcept C49039625 @default.
• W4236098219 hasConcept C71924100 @default.
• W4236098219 hasConcept C90924648 @default.
• W4236098219 hasConceptScore W4236098219C126322002 @default.
• W4236098219 hasConceptScore W4236098219C159654299 @default.
• W4236098219 hasConceptScore W4236098219C163764329 @default.
• W4236098219 hasConceptScore W4236098219C203014093 @default.
• W4236098219 hasConceptScore W4236098219C2775916456 @default.
• W4236098219 hasConceptScore W4236098219C2776986829 @default.
• W4236098219 hasConceptScore W4236098219C2777569460 @default.
• W4236098219 hasConceptScore W4236098219C2778248108 @default.
• W4236098219 hasConceptScore W4236098219C2778677798 @default.
• W4236098219 hasConceptScore W4236098219C2779422922 @default.
• W4236098219 hasConceptScore W4236098219C2779743957 @default.
• W4236098219 hasConceptScore W4236098219C2779750884 @default.
• W4236098219 hasConceptScore W4236098219C2779970781 @default.
• W4236098219 hasConceptScore W4236098219C2780342937 @default.
• W4236098219 hasConceptScore W4236098219C2780439177 @default.
• W4236098219 hasConceptScore W4236098219C2781443798 @default.
• W4236098219 hasConceptScore W4236098219C2910396959 @default.
• W4236098219 hasConceptScore W4236098219C3017897077 @default.
• W4236098219 hasConceptScore W4236098219C49039625 @default.
• W4236098219 hasConceptScore W4236098219C71924100 @default.
• W4236098219 hasConceptScore W4236098219C90924648 @default.
• W4236098219 hasLocation W42360982191 @default.
• W4236098219 hasOpenAccess W4236098219 @default.
• W4236098219 hasPrimaryLocation W42360982191 @default.
• W4236098219 hasRelatedWork W185058389 @default.
• W4236098219 hasRelatedWork W1854118839 @default.
• W4236098219 hasRelatedWork W186216973 @default.
• W4236098219 hasRelatedWork W1965379407 @default.
• W4236098219 hasRelatedWork W2056953791 @default.
• W4236098219 hasRelatedWork W2369224371 @default.
• W4236098219 hasRelatedWork W2513016706 @default.
• W4236098219 hasRelatedWork W3021732116 @default.
• W4236098219 hasRelatedWork W4236098219 @default.
• W4236098219 hasRelatedWork W2384280892 @default.
• W4236098219 isParatext "false" @default.
• W4236098219 isRetracted "false" @default.

• next