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• W4236127313 abstract "Background : Solid-pseudopapillary neoplasms of the pancreas (SPNs) are uncommon tumours usually frequent in young women. Although the pathogenesis of SPNs is uncertain a potential influence of the sex hormone milieu on the biology of these tumours has been suggested. The controversial expression of oestrogen receptors (ERs) in SPNs, provide a rationale for studying the effects of oestrogenic molecules on SPN development. Methods : The expression of a large series of hormonal ligands and receptors was evaluated in tissue specimens and in a primary cell culture (SPNC), obtained from a SPN in young female patient. The effects of 17 β -oestradiol (17 β E2), ICI 182,780 and tamoxifen (Tam) on cell replication and growth were examined. Results : We have established SPNC primary line. Immunocytochemical analysis was positive for vimentin, cyclin D1 and β -catenin and negative for cytokeratin, CD10 and neuroendocrine markers, in line with the immunostaining features of the tumoral tissue. Expression of ER α , ER β and progesterone mRNAs was demonstrated in SPNC and tumor tissue. A proliferative and antiproliferative action of 17 β E2 and Tam respectively were proved in SPNC. Conclusions : In conclusion, we provide the first direct evidence that oestrogenic molecules can influence proliferation of SPNC, offering future strategies in the control of this neoplasia via selective ER modulators." @default.
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• W4236127313 date "2010-01-01" @default.
• W4236127313 modified "2023-09-27" @default.
• W4236127313 title "<i>In Vitro</i> Effects of Oestrogens, Antioestrogens and SERMs on Pancreatic Solid Pseudopapillary Neoplasm-Derived Primary Cell Culture" @default.
• W4236127313 doi "https://doi.org/10.1155/2010/459862" @default.
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