Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236133733> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4236133733 endingPage "289" @default.
- W4236133733 startingPage "275" @default.
- W4236133733 abstract "T cell vaccine has been reported as being capable of regulating auto-reactive T cells in experimental autoimmune disease in mice and rats. In this paper we discuss the correction of auto-immunity in spontaneous autoimmune mice, MRL-lpr/lpr mice. Lymph node lymphocytes of younglpr mice were cultured in an anti-CD3 mAb immobilized dish in a medium containing recombinant interleukin-2, concanavalin A and ZnSO4 for a total of 7 days. These cells were then fixed and used as the T cell vaccine. The effects of this T cell vaccine were examined as: (i) lymphadenopathy by enumeration of lymph node lymphocytes; (ii) gross observation and histopathological examination of dermal lesions; (iii) measurement of the serum titer of the autoantibodies; and (iv) T cell subset analysis of lymph node lymphocytes by FACS. We found: (i) a decrease of lymphadenopathy (about one-third the value of the control); (ii) a marked delay in the onset of dermal lesions; (iii) a lowering of the serum titer of anti-double-stranded DNA antibody; and (iv) a decrease in the percentage of Thy-1.2+/B220+ T cells, accompanied by an increase in the percentage of Thy-1.2+/B220− T cells, in the T cell vaccinated mice. We conclude that T cell vaccine in its present form is partially effective in the correction of disease and abnormal T cell subsets inlpr mice. This treatment may also be feasible for the immunotherapy of human autoimmune diseases." @default.
- W4236133733 created "2022-05-12" @default.
- W4236133733 creator A5011824493 @default.
- W4236133733 creator A5022157564 @default.
- W4236133733 creator A5036256585 @default.
- W4236133733 creator A5049965454 @default.
- W4236133733 creator A5085297664 @default.
- W4236133733 creator A5085330772 @default.
- W4236133733 creator A5085561195 @default.
- W4236133733 date "1998-09-01" @default.
- W4236133733 modified "2023-09-26" @default.
- W4236133733 title "T cell vaccine against MRL-lpr/lpr mice" @default.
- W4236133733 cites W1934463538 @default.
- W4236133733 cites W1963923740 @default.
- W4236133733 cites W1964894552 @default.
- W4236133733 cites W1966577570 @default.
- W4236133733 cites W1972298443 @default.
- W4236133733 cites W1975520388 @default.
- W4236133733 cites W1999780541 @default.
- W4236133733 cites W2010968630 @default.
- W4236133733 cites W2040468592 @default.
- W4236133733 cites W2040595594 @default.
- W4236133733 cites W2053795255 @default.
- W4236133733 cites W2057885857 @default.
- W4236133733 cites W2074923160 @default.
- W4236133733 cites W2082773738 @default.
- W4236133733 cites W2089551606 @default.
- W4236133733 cites W2095447862 @default.
- W4236133733 cites W2100335079 @default.
- W4236133733 cites W2134090908 @default.
- W4236133733 cites W2139407204 @default.
- W4236133733 cites W2142269895 @default.
- W4236133733 cites W2146561639 @default.
- W4236133733 cites W4318357318 @default.
- W4236133733 doi "https://doi.org/10.1007/bf03041248" @default.
- W4236133733 hasPublicationYear "1998" @default.
- W4236133733 type Work @default.
- W4236133733 citedByCount "1" @default.
- W4236133733 crossrefType "journal-article" @default.
- W4236133733 hasAuthorship W4236133733A5011824493 @default.
- W4236133733 hasAuthorship W4236133733A5022157564 @default.
- W4236133733 hasAuthorship W4236133733A5036256585 @default.
- W4236133733 hasAuthorship W4236133733A5049965454 @default.
- W4236133733 hasAuthorship W4236133733A5085297664 @default.
- W4236133733 hasAuthorship W4236133733A5085330772 @default.
- W4236133733 hasAuthorship W4236133733A5085561195 @default.
- W4236133733 hasConcept C114684123 @default.
- W4236133733 hasConcept C159654299 @default.
- W4236133733 hasConcept C163764329 @default.
- W4236133733 hasConcept C167672396 @default.
- W4236133733 hasConcept C203014093 @default.
- W4236133733 hasConcept C2776090121 @default.
- W4236133733 hasConcept C2779075594 @default.
- W4236133733 hasConcept C2780849966 @default.
- W4236133733 hasConcept C2992881475 @default.
- W4236133733 hasConcept C32611913 @default.
- W4236133733 hasConcept C71924100 @default.
- W4236133733 hasConcept C8891405 @default.
- W4236133733 hasConceptScore W4236133733C114684123 @default.
- W4236133733 hasConceptScore W4236133733C159654299 @default.
- W4236133733 hasConceptScore W4236133733C163764329 @default.
- W4236133733 hasConceptScore W4236133733C167672396 @default.
- W4236133733 hasConceptScore W4236133733C203014093 @default.
- W4236133733 hasConceptScore W4236133733C2776090121 @default.
- W4236133733 hasConceptScore W4236133733C2779075594 @default.
- W4236133733 hasConceptScore W4236133733C2780849966 @default.
- W4236133733 hasConceptScore W4236133733C2992881475 @default.
- W4236133733 hasConceptScore W4236133733C32611913 @default.
- W4236133733 hasConceptScore W4236133733C71924100 @default.
- W4236133733 hasConceptScore W4236133733C8891405 @default.
- W4236133733 hasIssue "3" @default.
- W4236133733 hasLocation W42361337331 @default.
- W4236133733 hasOpenAccess W4236133733 @default.
- W4236133733 hasPrimaryLocation W42361337331 @default.
- W4236133733 hasRelatedWork W1963734927 @default.
- W4236133733 hasRelatedWork W1981231261 @default.
- W4236133733 hasRelatedWork W1992363163 @default.
- W4236133733 hasRelatedWork W2008154662 @default.
- W4236133733 hasRelatedWork W2047056828 @default.
- W4236133733 hasRelatedWork W2101875571 @default.
- W4236133733 hasRelatedWork W2405627905 @default.
- W4236133733 hasRelatedWork W2412943649 @default.
- W4236133733 hasRelatedWork W2425255793 @default.
- W4236133733 hasRelatedWork W4236133733 @default.
- W4236133733 hasVolume "8" @default.
- W4236133733 isParatext "false" @default.
- W4236133733 isRetracted "false" @default.
- W4236133733 workType "article" @default.