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- W4236166529 abstract "Abstract The effect of cyclosporin (CyA), FK 506, and mycophcnolate mofetil (MPM) on tumor growth was investigated using syngeneic mouse colon carcinoma 38. Mice were laparotomized and the tumor cells were injected into the portal vein to establish liver metastasis. The animals were grouped as follows: groups A-1, B-1, and C-1 were given CyA [15 mg/kg body weight (BW)], FK 506 (0.15 mg/kg BW), and MPM (100 mg/kg BW), respectively, 30 min before tumor inoculation and daily for 5 days by gavage; groups A-2, B-2, and C-2 were given CyA (30 mg/kg BW), FK 506 (0.3 mg/kg BW), and MPM (200 mg/kg BW), respectively, with the same dose timing; and groups A-3, B-3, and C-3 received CyA (30 mg/kg BW), FK 506 (0.3 mg/kg BW), and MPM (200 mg/kg BW), respectively, on the 7th post-tumor inoculation day and on the following 5 days. The mean tumor diameter in groups A-1 and C-2 was greater than that in the control group and in groups C-1 and C-2 at 3 weeks (P < 0.05). The mean tumor numbers in groups A-1 and A-2 were greater than those in the control group and in groups C-1 and C-2 at 4 weeks (P < 0.05). With in vitro MTT assay, all three drugs acted cytostatically on tumor cells with a higher concentration (10-6–10-4 mol/l), while no cytostatic effect was noted with CyA at a lower concentration (10-9–10-7 mol/l). Labeling indexes (%) by bromodeoxyuridine (BrdUrd) immunohisto-chemistry in groups A-1, A-2, and B-1 were significantly greater than those in the control group and in groups C-1 and C-2 (P < 0.05). Although the mechanism of cytoproliferative action of CyA and FK 506 is not well understood, a decrease in immunosurveillance capability by natural kill cells due to suppression of interleukin-2, their direct action as growth factors, and/or enhanced tumor cell adhesion can be considered." @default.
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- W4236166529 date "1995-07-01" @default.
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- W4236166529 title "Immunosuppressive drugs and their effect on experimental tumor growth" @default.
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- W4236166529 doi "https://doi.org/10.1111/j.1432-2277.1995.tb01517.x" @default.
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